Dynamic Combinatorial Chemistry to Identify Binders of ThiT, an S‐Component of the Energy‐Coupling Factor Transporter for Thiamine
Sign Up to like & getrecommendations! Published in 2017 at "Chemmedchem"
DOI: 10.1002/cmdc.201700440
Abstract: We applied dynamic combinatorial chemistry (DCC) to identify ligands of ThiT, the S‐component of the energy‐coupling factor (ECF) transporter for thiamine in Lactococcus lactis. We used a pre‐equilibrated dynamic combinatorial library (DCL) and saturation‐transfer difference… read more here.
Keywords: dynamic combinatorial; combinatorial chemistry; chemistry; thit component ... See more keywords
Development of Urease Inhibitors by Fragment‐Based Dynamic Combinatorial Chemistry
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DOI: 10.1002/cmdc.202200307
Abstract: In this study, fragment‐based dynamic combinatorial chemistry (DCC) was explored for the development of novel urease inhibitors. Based on a rationally designed fragment, two iteratively evolved dynamic combinatorial libraries (DCLs) were generated and screened in… read more here.
Keywords: fragment based; dynamic combinatorial; combinatorial chemistry; chemistry ... See more keywords
Effective synthetic strategy towards highly selective macrocyclic anion receptors based on static combinatorial chemistry
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron"
DOI: 10.1016/j.tet.2020.131693
Abstract: Abstract We present the synthesis, using combinatorial chemistry methodology, of a series of 11 selective anion receptors with special affinity for carboxylates. These compounds contain a urea function and their macrocyclic platform has the structure… read more here.
Keywords: combinatorial chemistry; synthetic strategy; chemistry; effective synthetic ... See more keywords
Dynamic Generation of G-Quadruplex DNA Ligands by Target-Guided Combinatorial Chemistry on a Magnetic Nanoplatform.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01459
Abstract: Dynamic combinatorial chemistry (DCC) has emerged as a promising strategy for template-driven selection of high-affinity ligands for biological targets from equilibrating combinatorial libraries. However, only a few examples using disulfide-exchange-based DCC are reported for nucleic… read more here.
Keywords: generation quadruplex; dna; combinatorial chemistry; quadruplex dna ... See more keywords
Fragment-Based Dynamic Combinatorial Chemistry for Identification of Selective α-Glucosidase Inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00405
Abstract: Efforts to combine advantages of fragment-based drug design (FBDD) and dynamic combinatorial chemistry (DCC) for the development of selective α-glucosidase inhibitors were described. Starting from 5 rationally designed fragments, two iterative dynamic combinatorial libraries (DCLs)… read more here.
Keywords: fragment based; selective glucosidase; dynamic combinatorial; combinatorial chemistry ... See more keywords
Cyclic Peptidic Furin Inhibitors Developed by Combinatorial Chemistry.
Sign Up to like & getrecommendations! Published in 2023 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.3c00008
Abstract: Furin is a human serine protease responsible for activating numerous physiologically relevant cell substrates and is also involved in the development of various pathological conditions, including inflammatory diseases, cancers, and viral and bacterial infections. Therefore,… read more here.
Keywords: furin; combinatorial chemistry; chemistry; inhibitor ... See more keywords
From Dynamic Combinatorial Chemistry to in Vivo Evaluation of Reversible and Irreversible Myeloperoxidase Inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.6b00417
Abstract: The implementation of dynamic combinatorial libraries allowed the determination of highly active reversible and irreversible inhibitors of myeloperoxidase (MPO) at the nanomolar level. Docking experiments highlighted the interaction between the most active ligands and MPO,… read more here.
Keywords: dynamic combinatorial; combinatorial chemistry; chemistry; vivo evaluation ... See more keywords
Discovery of a Biologically Active Bromodomain Inhibitor by Target-Directed Dynamic Combinatorial Chemistry.
Sign Up to like & getrecommendations! Published in 2018 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.8b00247
Abstract: Target-directed dynamic combinatorial chemistry (DCC) has emerged as a strategy for the identification of inhibitors of relevant therapeutic targets. In this contribution, we use this strategy for the identification of a high-affinity binder of a… read more here.
Keywords: dynamic combinatorial; target directed; combinatorial chemistry; chemistry ... See more keywords