Combinatorial expression of cell cycle regulators is more suitable for immortalization than oncogenic methods in dermal papilla cells
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DOI: 10.1016/j.isci.2020.101929
Abstract: Summary The immortalized cell is an essential research tool that uses robust growth properties for the functional investigation of gene products. Immortalized mammalian cells have mainly been established using three methods: expression of simian vacuolating… read more here.
Keywords: papilla cells; combinatorial expression; method; expression ... See more keywords
Combinatorial expression of GPCR isoforms affects signalling and drug responses
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DOI: 10.1038/s41586-020-2888-2
Abstract: G-protein-coupled receptors (GPCRs) are membrane proteins that modulate physiology across human tissues in response to extracellular signals. GPCR-mediated signalling can differ because of changes in the sequence 1 , 2 or expression 3 of the… read more here.
Keywords: drug responses; combinatorial expression; gpcr isoforms; gpcr ... See more keywords