Secretory Overexpression of Bacillus thermocatenulatus Lipase in Saccharomyces cerevisiae Using Combinatorial Library Strategy.
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology journal"
DOI: 10.1002/biot.201700409
Abstract: Simple and cost-effective lipase expression host microorganisms are highly desirable. A combinatorial library strategy is used to improve the secretory expression of lipase from Bacillus thermocatenulatus (BTL2) in the culture supernatant of Saccharomyces cerevisiae. A… read more here.
Keywords: saccharomyces cerevisiae; bacillus thermocatenulatus; lipase; combinatorial library ... See more keywords
Small Combinatorial Library of Lipidoids as Nanovectors for Gene Delivery
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DOI: 10.1021/acsanm.8b00688
Abstract: A small library of 27 lipidoids was set up by a combinatorial approach. These lipidoids were prepared from three polyamines and nine reactants with alkyl tail via epoxide ring-opening reaction or M... read more here.
Keywords: nanovectors gene; lipidoids nanovectors; library lipidoids; small combinatorial ... See more keywords
Emergence of a New Self-Replicator from a Dynamic Combinatorial Library Requires a Specific Pre-Existing Replicator
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b07346
Abstract: Our knowledge regarding the early steps in the formation of evolvable life and what constitutes the minimal molecular basis of life remains far from complete. The recent emergence of systems chemistry reinvigorated the investigation of… read more here.
Keywords: self replicator; dynamic combinatorial; replicator dynamic; combinatorial library ... See more keywords
Cell-Permeable Bicyclic Peptidyl Inhibitors against NEMO-IκB Kinase Interaction Directly from a Combinatorial Library.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b06738
Abstract: Macrocyclic peptides are capable of binding to flat protein surfaces such as the interfaces of protein-protein interactions with antibody-like affinity and specificity, but generally lack cell permeability in order to access intracellular targets. In this… read more here.
Keywords: permeable bicyclic; cell permeable; kinase; combinatorial library ... See more keywords
Aryl diazonium intermediates enable mild DNA-compatible C–C bond formation for medicinally relevant combinatorial library synthesis
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DOI: 10.1039/d2sc04482j
Abstract: Forging carbon–carbon (C–C) linkage in DNA-encoded combinatorial library synthesis represents a fundamental task for drug discovery, especially with broad substrate scope and exquisite functional group tolerance. Here we reported the palladium-catalyzed Suzuki–Miyaura, Heck and Hiyama… read more here.
Keywords: aryl diazonium; dna; synthesis; combinatorial library ... See more keywords
Combinatorial library design for improving isobutanol production in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.1080024
Abstract: Saccharomyces cerevisiae is the dominant fermentative producer of ethanol in industry and a preferred host for production of other biofuels. That said, rewiring the metabolism of S. cerevisiae to produce other fermentation products, such as… read more here.
Keywords: ethanol; combinatorial library; production; isobutanol pathway ... See more keywords
Structure-Based Design and Pharmacophore-Based Virtual Screening of Combinatorial Library of Triclosan Analogues Active against Enoyl-Acyl Carrier Protein Reductase of Plasmodium falciparum with Favourable ADME Profiles
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24086916
Abstract: Cost-effective therapy of neglected and tropical diseases such as malaria requires everlasting drug discovery efforts due to the rapidly emerging drug resistance of the plasmodium parasite. We have carried out computational design of new inhibitors… read more here.
Keywords: plasmodium; pharmacophore; combinatorial library; design ... See more keywords