P26.12.A REPURPOSING ITRACONAZOLE AND PYRIMETHAMINE WITH TEMOZOLOMIDE AS A COMBINATORIAL TREATMENT FOR GLIOBLASTOMA
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae144.460
Abstract: Glioblastoma (GB) is marked by a poor median overall survival of 14-16 months despite surgery, radiotherapy and chemotherapy, highlighting the need for improving treatment. Drug repurposing offers the advantage of using commercially available compounds with… read more here.
Keywords: treatment glioblastoma; treatment; itr pyr; combinatorial treatment ... See more keywords
EXTH-63. Repurposing itraconazole and pyrimethamine as a combinatorial treatment for glioblastoma
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.1396
Abstract: Glioblastoma (GBM) is marked by a poor median overall survival of 14-16 months, highlighting the need for improving treatment. Drug repurposing leverages existing, safe compounds to provide more effective, cost-efficient cancer treatments. Based on the… read more here.
Keywords: treatment; glioblastoma; gbm; itraconazole pyrimethamine ... See more keywords
P03.29 Characterization of treatment-induced adaptive immune responses in pancreatic ductal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-itoc7.67
Abstract: Background Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy marked by poor prognosis and profound drug resistance characterized in more than 90% of cases by KRAS mutations. To recapitulate central aspects of PDAC, we… read more here.
Keywords: pdac; none; combinatorial treatment; treatment ... See more keywords
Dichloroacetate nanoparticles and doxorubicin combinatorial treatment augment the hepato-renal function in Ehrlich ascites carcinoma cells
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DOI: 10.1186/s13104-025-07534-3
Abstract: Cancer cells are addressed through conventional chemotherapy, resulting in tumour resistance and systemic toxicities affecting organ functions. Nanoparticle (NPs) represent a promising approach to improve chemotherapeutic efficacy and reduce adverse effects. This study aims to… read more here.
Keywords: dichloroacetate nanoparticles; function; renal function; hepato renal ... See more keywords
High-throughput screen in vitro identifies dasatinib as a candidate for combinatorial treatment with HER2-targeting drugs in breast cancer
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DOI: 10.1371/journal.pone.0280507
Abstract: Human epidermal growth factor receptor 2-positive (HER2+) breast cancer is an aggressive subtype of this disease. Targeted treatment has improved outcome, but there is still a need for new therapeutic strategies as some patients respond… read more here.
Keywords: breast cancer; treatment; her2; combinatorial treatment ... See more keywords
A novel combinatorial treatment option for metastatic uveal melanoma
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DOI: 10.18632/oncotarget.25445
Abstract: Uveal melanoma (UM) is the most frequent intraocular tumor in adult patients. When metastases occur, systemic therapy with alkylating agents (fotemustine or dacarbazine (DTIC)) has shown only modest efficacy. The common chemotherapeutic drug doxorubicin (DOX)… read more here.
Keywords: melanoma; novel combinatorial; uveal melanoma; creb knockdown ... See more keywords
Combined Phytochemical Sulforaphane and Dietary Fiber Inulin Contribute to the Prevention of ER-Negative Breast Cancer via PI3K/AKT/MTOR Pathway and Modulating Gut Microbial Composition
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DOI: 10.3390/nu17122023
Abstract: Background: Breast cancer (BC) is the second most common cancer among women in the United States. It has been estimated that one in eight women will be diagnosed with breast cancer in her lifetime. Various… read more here.
Keywords: cancer; breast cancer; inulin; prevention ... See more keywords