Combinatorial use of disulfide bridges and native sulfur-SAD phasing for rapid structure determination of coiled-coils
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DOI: 10.1042/bsr20181073
Abstract: Coiled-coils are ubiquitous protein–protein interaction motifs found in many eukaryotic proteins. The elongated, flexible and often irregular nature of coiled-coils together with their tendency to form fibrous arrangements in crystals imposes challenges on solving the… read more here.
Keywords: sulfur sad; coiled coils; sad phasing; combinatorial use ... See more keywords
Abstract 397: Combinatorial use of VHL and KEAP1-based PROTACs reveals unexpected synergy and hook effect relief
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DOI: 10.1158/1538-7445.am2025-397
Abstract: Proteolysis-targeting chimeras (PROTACs) are bifunctional molecules bridging a target protein with an E3 ubiquitin ligase, promoting its ubiquitylation and degradation. Unlike traditional inhibitors, PROTACs exploit transient interactions, enabling the selective degradation of “undruggable” proteins, thereby… read more here.
Keywords: hook effect; vhl; use vhl; combinatorial use ... See more keywords