Effect of Combined Immune Checkpoint Inhibition vs Best Supportive Care Alone in Patients With Advanced Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2020 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2020.0910
Abstract: Key Points Question Can combined immune checkpoint inhibition improve overall survival (OS) in patients with advanced refractory colorectal cancer (CRC)? Findings In this randomized phase 2 study with 180 patients randomized in a 2:1 ratio… read more here.
Keywords: immune checkpoint; combined immune; supportive care; checkpoint inhibition ... See more keywords
Hyperthermia combined with immune checkpoint inhibitor therapy: Synergistic sensitization and clinical outcomes
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DOI: 10.1002/cam4.5085
Abstract: Within the field of oncotherapy, research interest regarding immunotherapy has risen to the point that it is now seen as a key application. However, inherent disadvantages of immune checkpoint inhibitors (ICIs), such as their low… read more here.
Keywords: checkpoint inhibitor; immune checkpoint; combined immune; hyperthermia combined ... See more keywords
Adenosine Deaminase (ADA)-Deficient Severe Combined Immune Deficiency (SCID): Molecular Pathogenesis and Clinical Manifestations
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Immunology"
DOI: 10.1007/s10875-017-0433-3
Abstract: Deficiency of adenosine deaminase (ADA, EC3.5.4.4), a housekeeping enzyme of purine metabolism encoded by the Ada gene, is a cause of human severe combined immune deficiency (SCID). Numerous deleterious mutations occurring in the ADA gene… read more here.
Keywords: combined immune; immune deficiency; adenosine deaminase; deficiency ... See more keywords
Combined immune checkpoint blockade (anti-PD-1/anti-CTLA-4): Evaluation and management of adverse drug reactions.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer treatment reviews"
DOI: 10.1016/j.ctrv.2017.05.003
Abstract: BACKGROUND Combined immune checkpoint blockade (ICB) provides unprecedented efficacy gains in numerous cancer indications, with PD-1 inhibitor nivolumab plus CTLA-4 inhibitor ipilimumab in advanced melanoma as first-ever approved therapies for combined ICB. However, gains in… read more here.
Keywords: checkpoint blockade; immune checkpoint; combined immune; anti ... See more keywords
Efficacy of radiotherapy combined with immune checkpoint inhibitors in patients with melanoma: a systemic review and meta-analysis
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DOI: 10.1097/cmr.0000000000000800
Abstract: Supplemental Digital Content is available in the text. The purpose of this study is to review the efficacy of radiotherapy combined with immune checkpoint inhibitors (ICIs) in the treatment of melanoma and systematically evaluate the… read more here.
Keywords: efficacy radiotherapy; combined immune; radiotherapy; radiotherapy combined ... See more keywords
Clinical, Immunological, and Molecular Features of Severe Combined Immune Deficiency: A Multi-Institutional Experience From India
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.619146
Abstract: Background Severe Combined Immune Deficiency (SCID) is an inherited defect in lymphocyte development and function that results in life-threatening opportunistic infections in early infancy. Data on SCID from developing countries are scarce. Objective To describe… read more here.
Keywords: combined immune; scid; immune deficiency; immunology ... See more keywords