Prognostic value of PD-L1 combined positive score in patients with upper tract urothelial carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-021-02890-y
Abstract: Upper tract urothelial carcinoma (UTUC) is relatively rare in Western countries. The impact of programmed death-ligand 1 (PD-L1) expression on UTUC remains unclear because previous studies have focused on bladder UC. We investigated the association… read more here.
Keywords: upper tract; tract urothelial; positive score; urothelial carcinoma ... See more keywords
Combined Positive and Negative Feedback Allows Modulation of Neuronal Oscillation Frequency during Sensory Processing.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.10.029
Abstract: A key step in sensory information processing involves modulation and integration of neuronal oscillations in disparate frequency bands, a poorly understood process. Here, we investigate how top-down input causes frequency changes in slow oscillations during… read more here.
Keywords: modulation; frequency; oscillatory behaviors; sensory processing ... See more keywords
Efficacy of Pembrolizumab Monotherapy for Advanced Gastric/Gastroesophageal Junction Cancer with Programmed Death Ligand 1 Combined Positive Score ≥10
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-20-2980
Abstract: Purpose: Pembrolizumab demonstrated efficacy in PD-L1–positive [combined positive score (CPS) ≥1] advanced gastric/gastroesophageal junction (G/GEJ) cancer in the first-, second-, and third-line setting in KEYNOTE-062, KEYNOTE-061, and KEYNOTE-059, respectively. To better delineate the specificity of… read more here.
Keywords: months versus; combined positive; efficacy; versus months ... See more keywords
Abstract 749: Pathology training for combined positive score algorithm for the assessment of PD-L1 in human cancer tissues
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Trials"
DOI: 10.1158/1538-7445.am2020-749
Abstract: Introduction: A pathologist training and testing procedure was developed for evaluating PD-L1 expression using the Combined Positive Score (CPS) algorithm, with effectiveness assessed by examining the results of scoring reproducibility studies. Background: The CPS algorithm… read more here.
Keywords: pathology; positive score; cps algorithm; cancer ... See more keywords
Development of the combined positive score (CPS) for the evaluation of PD-L1 in solid tumors with the immunohistochemistry assay PD-L1 IHC 22C3 pharmDx.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e14589
Abstract: e14589Background: Developing clinically relevant and highly reproducible scoring methods for PD-L1 to identify patients who will respond effectively to anti-PD-1 therapy is key in the development o... read more here.
Keywords: positive score; development combined; combined positive; development ... See more keywords
Cost-effectiveness analysis of pembrolizumab for patients with advanced esophageal cancer at PD-L1 combined positive score ≥10.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of comparative effectiveness research"
DOI: 10.2217/cer-2021-0165
Abstract: Aim: Due to the high price of pembrolizumab, it is still unknown whether the use of pembrolizumab for advanced esophageal cancer would be a cost-effective option for patients whose PD-L1 combined positive score is ≥10. Methods:… read more here.
Keywords: esophageal cancer; advanced esophageal; cost; effectiveness ... See more keywords
Combined Positive Score for Programmed Death Ligand-1 Expression and Inflammatory Microenvironment in Gastrointestinal Stromal Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Medicina"
DOI: 10.3390/medicina58020174
Abstract: Background and Objectives: GISTs are the most frequent type of mesenchymal neoplasm of the digestive tract. The prognosis is mainly determined by tumor dimensions, mitotic rate and location, but other less well-documented factors can influence… read more here.
Keywords: expression; type; immune cells; positive score ... See more keywords