Combined targeting of HEDGEHOG signaling and BRD4 as a novel therapeutic option against melanoma
Sign Up to like & getrecommendations! Published in 2023 at "Oncotarget"
DOI: 10.18632/oncotarget.28441
Abstract: The Hedgehog-GLI (HH/GLI) pathway is aberrantly activated in several types of cancer. Canonical HH/ GLI pathway is triggered by binding of HH ligands to the twelve-pass transmembrane receptor Patched 1 (PTCH1), which retrieves its inhibition… read more here.
Keywords: hedgehog signaling; hedgehog; targeting hedgehog; gli ... See more keywords
Combined Targeting of Estrogen Receptor Alpha and XPO1 Prevent Akt Activation, Remodel Metabolic Pathways and Induce Autophagy to Overcome Tamoxifen Resistance
Sign Up to like & getrecommendations! Published in 2019 at "Cancers"
DOI: 10.3390/cancers11040479
Abstract: A majority of breast cancer specific deaths in women with ERĪ± (+) tumors occur due to metastases that are resistant to endocrine therapy. There is a critical need for novel therapeutic approaches to resensitize recurrent… read more here.
Keywords: akt; combined targeting; metabolic pathways; resistance ... See more keywords