Discovery of inhibitors targeting protein tyrosine phosphatase 1B using a combined virtual screening approach.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular diversity"
DOI: 10.1007/s11030-021-10323-2
Abstract: Protein tyrosine phosphatase 1B (PTP1B) acts as a therapeutic target for type 2 diabetes. However, the major challenges of PTP1B drug discovery are the poor selectivity and the weak oral bioavailability. In this study, we… read more here.
Keywords: virtual screening; tyrosine phosphatase; combined virtual; protein tyrosine ... See more keywords
Identification of novel antiplatelet agents by targeting Glycoprotein VI: A combined virtual screening study.
Sign Up to like & getrecommendations! Published in 2022 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2022.105661
Abstract: Cardiovascular diseases are the primary reason for deaths in the world. However, antiplatelet drugs in the market have limitations in use because of the risk of increased bleeding and other side effects that impair primary… read more here.
Keywords: study; antiplatelet agents; combined virtual; virtual screening ... See more keywords