Combining the Best of Two Chelating Titans: A Hydroxypyridinone-Decorated Macrocyclic Ligand for Efficient and Concomitant Complexation and Sensitized Luminescence of f-Elements.
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DOI: 10.1002/cplu.202100083
Abstract: An ideal chelator for f-elements features rapid kinetics of complexation, high thermodynamic stability, and slow kinetics of dissociation. Here we present the facile synthesis of a macrocyclic ligand bearing four 1-hydroxy-2-pyridinone units linked to a… read more here.
Keywords: macrocyclic ligand; best two; combining best; two chelating ... See more keywords
Computational design of an amidase by combining the best electrostatic features of two promiscuous hydrolases
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DOI: 10.1039/d2sc00778a
Abstract: While there has been emerging interest in designing new enzymes to solve practical challenges, computer-based options to redesign catalytically active proteins are rather limited. Here, a rational QM/MM molecular dynamics strategy based on combining the… read more here.
Keywords: amidase; best electrostatic; computational design; combining best ... See more keywords
Combining the best of both worlds: radical-based divergent total synthesis
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DOI: 10.3762/bjoc.19.1
Abstract: A mature science, combining the art of the total synthesis of complex natural structures and the practicality of delivering highly diverged lead compounds for biological screening, is the constant aim of the organic chemistry community.… read more here.
Keywords: chemistry; synthesis; best worlds; combining best ... See more keywords