Structure Determination of Challenging Protein-Peptide Complexes Combining NMR Chemical Shift Data and Molecular Dynamics Simulations
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DOI: 10.1021/acs.jcim.2c01595
Abstract: Intrinsically disordered regions of proteins often mediate important protein-protein interactions. However, the folding-upon-binding nature of many polypeptide-protein interactions limits the ability of modeling tools to predict the three-dimensional structures of such complexes. To address this… read more here.
Keywords: shift data; chemical shift; combining nmr; peptide ... See more keywords