Combretastatin analogues in cancer biology: A prospective view
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29342
Abstract: The stilbenoid combretastatin and its derivatives are potent inhibitors of angiogenesis and cell proliferation and induce apoptosis. They disrupt cytoskeletal dynamics and modulate cell morphology, motility, and invasion. Hence they have been viewed as potential… read more here.
Keywords: combretastatin analogues; biology; cancer biology; combretastatin ... See more keywords
Suppression of angiogenesis and tumour progression by combretastatin and derivatives.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.06.032
Abstract: The search for small molecule inhibitors has gained prominence with the recognition of their inherent advantage for cancer therapy. Combretastatin is a naturally occurring small stilbenoid. By virtue of the ability to bind to tubulin… read more here.
Keywords: angiogenesis tumour; suppression angiogenesis; combretastatin derivatives; tumour progression ... See more keywords
Photoresponsive azo-combretastatin A-4 analogues.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.11.012
Abstract: Colchicine analogues in which an azo group is incorporated into a molecule containing the key pharmacophore of colchicine, have found particular utility as switchable tubulin binding chemotherapeutics. Combretastatin is a related compound containing a stilbene… read more here.
Keywords: azo combretastatin; photoresponsive azo; chemistry; ic50 ... See more keywords
Evaluation of lipid-stabilised tripropionin nanodroplets as a delivery route for combretastatin A4.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.05.009
Abstract: Lipid-based nanoemulsions are a cheap and elegant route for improving the delivery of hydrophobic drugs. Easy and quick to prepare, nanoemulsions have promise for the delivery of different therapeutic agents. Although multiple studies have investigated… read more here.
Keywords: lipid stabilised; combretastatin; evaluation lipid; delivery ... See more keywords
Development of Combretastatin A-4 Analogues as Potential Anticancer Agents with Improved Aqueous Solubility
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28041717
Abstract: Combretastatin A-4 (CA-4) is a potent tubulin polymerisation inhibitor. However, the clinical application of CA-4 is limited owing to its low aqueous solubility and the easy conversion of the olefin double bond from the more… read more here.
Keywords: compound; solubility; development; aqueous solubility ... See more keywords
Pharmacokinetic Profile Evaluation of Novel Combretastatin Derivative, LASSBio-1920, as a Promising Colorectal Anticancer Agent
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15041282
Abstract: LASSBio-1920 was synthesized due to the poor solubility of its natural precursor, combretastatin A4 (CA4). The cytotoxic potential of the compound against human colorectal cancer cells (HCT-116) and non-small cell lung cancer cells (PC-9) was… read more here.
Keywords: profile evaluation; evaluation novel; pharmacokinetic profile; lassbio 1920 ... See more keywords