Synthesis and biological evaluation of pyrimidine bridged combretastatin derivatives as potential anticancer agents and mechanistic studies.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.02.027
Abstract: A number of pyrimidine bridged combretastatin derivatives were designed, synthesized and evaluated for anticancer activities against breast cancer (MCF-7) and lung cancer (A549) cell lines using MTT assays. Most of the synthesized compounds displayed good… read more here.
Keywords: biological evaluation; bridged combretastatin; combretastatin derivatives; cancer ... See more keywords
Suppression of angiogenesis and tumour progression by combretastatin and derivatives.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.06.032
Abstract: The search for small molecule inhibitors has gained prominence with the recognition of their inherent advantage for cancer therapy. Combretastatin is a naturally occurring small stilbenoid. By virtue of the ability to bind to tubulin… read more here.
Keywords: angiogenesis tumour; suppression angiogenesis; combretastatin derivatives; tumour progression ... See more keywords