Combretastatin A4-derived payloads for antibody-drug conjugates.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113355
Abstract: We describe the use of natural product combretastatin A4 (CA4) as a versatile new payload for the construction of antibody-drug conjugates (ADCs). Cetuximab conjugates consisting of CA4 derivatives were site-specially prepared by disulfide re-bridging approach… read more here.
Keywords: drug conjugates; derived payloads; combretastatin derived; antibody drug ... See more keywords