Neurotrophic Action of Comenic Acid and Its Derivatives Potassium Comenate and Calcium Comenate
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DOI: 10.1007/s10517-018-4195-6
Abstract: Using the model of cultured spinal ganglia, we demonstrated high neurotrophic activity of comenic acid and its derivatives potassium comenate and calcium comenate both under normal conditions and during oxidative stress. Calcium comenate in the… read more here.
Keywords: calcium; calcium comenate; acid derivatives; comenic acid ... See more keywords
Synthesis and Biological Activity of Novel Comenic Acid Derivatives Containing Isoxazole and Isothiazole Moieties
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DOI: 10.1177/1934578x1801301124
Abstract: Methyl 5-hydroxy-4-oxo-4H-pyran-2-carboxylate was synthesized by esterification of methanol with comenic acid under acidic catalysis. The obtained ester was alkylated with 3-(chloromethyl)-5-phenylisoxazole and 4,5-dichloro-3-(chloromethyl)isothiazole to afford corresponding conjugates containing isoxazole and isothiazole moieties which then were… read more here.
Keywords: isothiazole moieties; isoxazole isothiazole; containing isoxazole; synthesis biological ... See more keywords