Are antibacterial effects of non-antibiotic drugs random or purposeful because of a common evolutionary origin of bacterial and mammalian targets?
Sign Up to like & getrecommendations! Published in 2020 at "Infection"
DOI: 10.1007/s15010-020-01547-9
Abstract: Advances in structural biology, genetics, bioinformatics, etc. resulted in the availability of an enormous pool of information enabling the analysis of the ancestry of pro- and eukaryotic genes and proteins. This review summarizes findings of… read more here.
Keywords: non antibiotics; bacterial mammalian; evolutionary origin; mammalian targets ... See more keywords
Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts
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DOI: 10.1111/joim.12993
Abstract: Mass extinctions occur frequently in natural history. While studies of animals that became extinct can be informative, it is the survivors that provide clues for mechanisms of adaptation when conditions are adverse. Here, we describe… read more here.
Keywords: metabolism common; fructose metabolism; common evolutionary; pathway ... See more keywords
A common evolutionary origin reveals fundamental principles of protein insertases
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DOI: 10.1371/journal.pbio.3001558
Abstract: Membrane proteins require protein machineries to insert their hydrophobic transmembrane domains (TMDs) into the lipid bilayer. A functional analysis of protein insertases in this issue of PLOS Biology reveals that the fundamental mechanism of membrane… read more here.
Keywords: reveals fundamental; common evolutionary; protein insertases; origin reveals ... See more keywords
Novel Circoviruses from Birds Share Common Evolutionary Roots with Fish Origin Circoviruses
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DOI: 10.3390/life12030368
Abstract: Circoviruses occur in a variety of animal species and are common pathogens of mammalian and avian hosts. In our study internal organ samples of wild birds were processed for screening of circoviral sequences. Two novel… read more here.
Keywords: novel circoviruses; common evolutionary; evolutionary roots; circoviruses birds ... See more keywords