Discovery of novel MurB inhibitors through common feature pharmacophore–based virtual screening and in vitro biological evaluation
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the Chinese Chemical Society"
DOI: 10.1002/jccs.70127
Abstract: MurB, a key enzyme involved in bacterial cell wall synthesis, has become an important target in antibacterial drug research due to its crucial role in inhibiting peptidoglycan biosynthesis. In this study, a virtual screening workflow… read more here.
Keywords: virtual screening; evaluation; vitro biological; feature pharmacophore ... See more keywords
Failure to recombine is a common feature of human oogenesis.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2020.11.010
Abstract: Failure of homologous chromosomes to recombine is arguably the most important cause of human meiotic nondisjunction, having been linked to numerous autosomal and sex chromosome trisomies of maternal origin. However, almost all information on these… read more here.
Keywords: common feature; failure recombine; failure; recombine common ... See more keywords
Severe exudative vitreoretinopathy as a common feature for CTNNB1, KIF11 and NDP variants plus sector degeneration for KIF11.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of ophthalmology"
DOI: 10.1016/j.ajo.2021.09.017
Abstract: PURPOSE To characterize ocular phenotypes in patients with CTNNB1, KIF11, or NDP variants. DESIGN Retrospective case series. METHODS Seventy-four patients from 59 unrelated families with CTNNB1, KIF11, and NDP variants were enrolled based on exome… read more here.
Keywords: ndp variants; exudative vitreoretinopathy; common feature; ctnnb1 kif11 ... See more keywords
SmithRNAs: A Common Feature among Metazoa
Sign Up to like & getrecommendations! Published in 2025 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evaf208
Abstract: Abstract SmithRNAs are a novel class of small noncoding RNAs that are encoded in the mitochondrial genome and regulate the expression of nuclear transcripts. They have been recently described in the Manila clam Ruditapes philippinarum… read more here.
Keywords: feature among; smithrnas common; metazoa smithrnas; feature ... See more keywords
A Common Feature of Pesticides: Oxidative Stress—The Role of Oxidative Stress in Pesticide-Induced Toxicity
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/5563759
Abstract: Pesticides are important chemicals or biological agents that deter or kill pests. The use of pesticides has continued to increase as it is still considered the most effective method to reduce pests and increase crop… read more here.
Keywords: common feature; stress; pesticide induced; toxicity ... See more keywords
Modeling the PAX5P80R Mutation Reveals HIF2α Activation as a Common Feature and Therapeutic Target in B-Cell Acute Lymphoblastic Leukemia.
Sign Up to like & getrecommendations! Published in 2025 at "Cancer research"
DOI: 10.1158/0008-5472.can-24-1698
Abstract: The transcription factor PAX5 is a major target of genetic alterations in human B-cell precursor acute lymphoblastic leukemia (B-ALL). Among the alterations, the P80R mutation affecting the DNA-binding domain represents the most frequent PAX5 point… read more here.
Keywords: acute lymphoblastic; lymphoblastic leukemia; cell; mutation ... See more keywords
Neuroinflammation as a Common Feature of Neurodegenerative Disorders
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.01008
Abstract: Neurodegenerative diseases share the fact that they derive from altered proteins that undergo an unfolding process followed by formation of β-structures and a pathological tendency to self-aggregate in neuronal cells. This is a characteristic of… read more here.
Keywords: protein; feature neurodegenerative; common feature; neuroinflammation common ... See more keywords