Common Fragile Sites Are Characterized by Faulty Condensin Loading after Replication Stress
Sign Up to like & getrecommendations! Published in 2020 at "Cell Reports"
DOI: 10.1016/j.celrep.2020.108177
Abstract: Summary Cells coordinate interphase-to-mitosis transition, but recurrent cytogenetic lesions appear at common fragile sites (CFSs), termed CFS expression, in a tissue-specific manner after replication stress, marking regions of instability in cancer. Despite such a distinct… read more here.
Keywords: common fragile; replication; replication stress; condensin loading ... See more keywords
Replication stress induces POLQ-mediated structural variant formation throughout common fragile sites after entry into mitosis
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-53917-8
Abstract: Genomic structural variants (SVs) greatly impact human health, but much is unknown about the mechanisms that generate the largest class of nonrecurrent alterations. Common fragile sites (CFSs) are unstable loci that provide a model for… read more here.
Keywords: replication stress; polq mediated; fragile sites; formation ... See more keywords
New Era of Mapping and Understanding Common Fragile Sites: An Updated Review on Origin of Chromosome Fragility
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.906957
Abstract: Common fragile sites (CFSs) are specific genomic loci prone to forming gaps or breakages upon replication perturbation, which correlate well with chromosomal rearrangement and copy number variation. CFSs have been actively studied due to their… read more here.
Keywords: common fragile; origin; cfss; fragile sites ... See more keywords
Recurrent alterations of the WW domain containing oxidoreductase gene spanning the common fragile site FRA16D in multiple myeloma and monoclonal gammopathy of undetermined significance.
Sign Up to like & getrecommendations! Published in 2017 at "Oncology letters"
DOI: 10.3892/ol.2017.6672
Abstract: The putative tumor suppressor gene WW domain containing oxidoreductase (WWOX) spans a common fragile site (CFS) on chromosome 16q23.3. CFSs are regions of profound genomic instability and sites for genomic deletions in cancer cells. Therefore,… read more here.
Keywords: domain containing; methylation; containing oxidoreductase; multiple myeloma ... See more keywords