Ubc9 deficiency selectively impairs the functionality of common lymphoid progenitors (CLPs) during bone marrow hematopoiesis.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular immunology"
DOI: 10.1016/j.molimm.2019.08.003
Abstract: Hematopoietic development occurs in the bone marrow, and this process begins with hematopoietic stem cells (HSCs). Ubc9 is a unique E2-conjugating enzyme required for SUMOylation, an evolutionarily conserved post-translational modification system. We herein show that… read more here.
Keywords: progenitors clps; lymphoid progenitors; bone; common lymphoid ... See more keywords
Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors.
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2017-09-805259
Abstract: Common lymphoid progenitors (CLPs) differentiate to T and B lymphocytes, dendritic cells, natural killer cells, and innate lymphoid cells. Here, we describe culture conditions that, for the first time, allow the establishment of lymphoid-restricted, but… read more here.
Keywords: lines clones; term proliferating; long term; lymphoid progenitors ... See more keywords
C/EBPα induces Ebf1 gene expression in common lymphoid progenitors
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DOI: 10.1371/journal.pone.0244161
Abstract: C/EBPα is required for formation of granulocyte-monocyte progenitors (GMP) and also participates in B lymphopoiesis. The common lymphoid progenitor (CLP) and preproB populations but not proB cells express Cebpa, and pan-hematopoietic deletion of the +37… read more here.
Keywords: clp; cebpa; deletion; common lymphoid ... See more keywords