A Common Mechanism Links Activities of Butyrate in the Colon.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.8b00073
Abstract: Two biological activities of butyrate in the colon (suppression of proliferation of colonic epithelial stem cells and inflammation) correlate with inhibition of the activity of histone deacetylases. Cellular and biochemical studies of molecules similar in… read more here.
Keywords: butyrate colon; activities butyrate; common mechanism; histone deacetylases ... See more keywords
Epithelial-mesenchymal transition (EMT) beyond EGFR mutations per se is a common mechanism for acquired resistance to EGFR TKI
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0454-2
Abstract: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) is a major advance in treating NSCLC with EGFR-activating mutations. However, acquired resistance, due partially to secondary mutations limits their use. Here we report that NSCLC… read more here.
Keywords: egfr mutations; common mechanism; acquired resistance; resistance ... See more keywords
A common mechanism for evolution of single shear bands in large-strain deformation of metals
Sign Up to like & getrecommendations! Published in 2018 at "Philosophical Magazine"
DOI: 10.1080/14786435.2018.1524586
Abstract: ABSTRACT Shear banding, a type of inhomogeneous plastic flow involving very large local strains, occurs in a variety of material systems. We study dynamics of evolution of single shear bands at strain rates of up… read more here.
Keywords: common mechanism; deformation; single shear; shear bands ... See more keywords
A common mechanism of Sec61 translocon inhibition by small molecules
Sign Up to like & getrecommendations! Published in 2022 at "Nature Chemical Biology"
DOI: 10.1101/2022.08.11.503542
Abstract: Itskanov and Wang et al. determined high-resolution structures of the human Sec61 channel inhibited by several structurally distinct small molecules and revealed the common inhibitor-binding site in Sec61 and molecular interactions in atomic detail. The… read more here.
Keywords: translocon inhibition; sec61 translocon; mechanism sec61; small molecules ... See more keywords
A common mechanism modulates saccade timing during pursuit and fixation.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of neurophysiology"
DOI: 10.1152/jn.00198.2019
Abstract: Smooth pursuit is punctuated by catch-up saccades, which are thought to automatically correct sensory errors in retinal position and velocity. Recent studies have shown that the timing of catch-up saccades is susceptible to cognitive modulation,… read more here.
Keywords: fixation; common mechanism; catch; pursuit ... See more keywords
Increasing Aspartoacylase in the Central Amygdala: The Common Mechanism of Gastroprotective Effects of Monoamine-Based Antidepressants Against Stress
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.823291
Abstract: Monoamine-based antidepressants can prophylactically protect against stress-induced gastric ulcers. Although the central nucleus of amygdala (CeA) has been shown to modulate the severity of stress ulcers, little is known about the molecular mechanisms underlying the… read more here.
Keywords: mechanism gastroprotective; monoamine based; gastroprotective effects; based antidepressants ... See more keywords