Discovery of MK-6169, a Potent Pan-Genotype Hepatitis C Virus NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Substitutions.
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DOI: 10.1021/acs.jmedchem.7b01927
Abstract: We describe the discovery of MK-6169, a potent and pan-genotype hepatitis C virus NS5A inhibitor with optimized activity against common resistance-associated substitutions. SAR studies around the combination of changes to both the valine and aminal… read more here.
Keywords: 6169 potent; associated substitutions; resistance associated; common resistance ... See more keywords