Maternal common variant rs2305957 spanning PLK4 is associated with blastocyst formation and early recurrent miscarriage.
Sign Up to like & getrecommendations! Published in 2017 at "Fertility and sterility"
DOI: 10.1016/j.fertnstert.2017.01.006
Abstract: OBJECTIVE To investigate whether the common variant rs2305957 spanning PLK4 (Polo-like kinase 4) confers risk to embryo development in Northern Chinese Han (CHN) women. DESIGN Genetic association study. SETTING University hospital. PATIENT(S) A total of… read more here.
Keywords: common variant; blastocyst formation; rs2305957; variant rs2305957 ... See more keywords
Erratum: Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families (Neuron (2018) 98(4) (743–753.e4), (S0896627318303222) (10.1016/j.neuron.2018.04.014))
Sign Up to like & getrecommendations! Published in 2018 at "Neuron"
DOI: 10.1016/j.neuron.2018.08.029
Abstract: (Neuron 98, 743–753.e1–e4; May 16, 2018) In the original publication of this paper, the middle initial of Michael D. Ferrari's name was inadvertently left out. This has since been corrected online. The authors apologize for… read more here.
Keywords: 743 753; common variant; erratum common; variant burden ... See more keywords
rs3751812, a common variant in fat mass and obesity-associated (FTO) gene, is associated with serum high- and low-density lipoprotein cholesterol in Pakistani individuals.
Sign Up to like & getrecommendations! Published in 2017 at "Nutrition"
DOI: 10.1016/j.nut.2016.04.008
Abstract: OBJECTIVES The aim of the present study was to investigate the effect of a common variant of the fat mass and obesity associated (FTO) gene, rs3751812 in obese Pakistani individuals, compare this effect with nonobese… read more here.
Keywords: common variant; variant fat; mass; cholesterol ... See more keywords
Pairwise common variant meta-analyses of schizophrenia with other psychiatric disorders reveals shared and distinct gene and gene-set associations
Sign Up to like & getrecommendations! Published in 2020 at "Translational Psychiatry"
DOI: 10.1038/s41398-020-0817-7
Abstract: The complex aetiology of schizophrenia is postulated to share components with other psychiatric disorders. We investigated pleiotropy amongst the common variant genomics of schizophrenia and seven other psychiatric disorders using a multimarker association test. Transcriptomic… read more here.
Keywords: schizophrenia psychiatric; gene set; common variant; psychiatric disorders ... See more keywords
Common Treatment, Common Variant: Evolutionary Prediction of Functional Pharmacogenomic Variants
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm11020131
Abstract: Pharmacogenomics holds the promise of personalized drug efficacy optimization and drug toxicity minimization. Much of the research conducted to date, however, suffers from an ascertainment bias towards European participants. Here, we leverage publicly available, whole… read more here.
Keywords: common treatment; common variant; treatment common; xgb pgx ... See more keywords