Glimepiride and glibenclamide have comparable efficacy in treating acute ischemic stroke in mice
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.107845
Abstract: Glibenclamide protects against ischemic injury in both preclinical and clinical studies, presumably by blocking the de novo assembled sulfonylurea receptor 1-transient receptor potential M4 (Sur1-Trpm4) channel induced by ischemia. However, glibenclamide may cause unexpected serious… read more here.
Keywords: glibenclamide; ischemic stroke; comparable efficacy; mice ... See more keywords
Comparable efficacy and safety of brodalumab in obese and nonobese patients with psoriasis: analysis of two randomized controlled trials
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Dermatology"
DOI: 10.1111/bjd.18327
Abstract: Obesity is associated with psoriasis and negatively affects response to therapy. read more here.
Keywords: brodalumab obese; safety brodalumab; nonobese patients; efficacy safety ... See more keywords