The first biosimilar approved for the treatment of osteoporosis: results of a comparative pharmacokinetic/pharmacodynamic study
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DOI: 10.1007/s00198-018-4741-0
Abstract: SummaryTo demonstrate the clinical comparability between RGB-10 (a biosimilar teriparatide) and the originator, a comparative pharmacokinetic trial was conducted. The study was successful in establishing bioequivalence. Marketing authorisation for RGB-10 (Terrosa®) was granted by the… read more here.
Keywords: comparative pharmacokinetic; study; biosimilar approved; pharmacokinetic pharmacodynamic ... See more keywords
Comparative Pharmacokinetic Study of Two Pyrrolizidine Alkaloids Lasiocarpine and Heliotrine in Rats
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DOI: 10.1055/a-1915-5456
Abstract: Abstract Lasiocarpine (LAS) and heliotrine (HEL) are two different ester types of toxic pyrrolizidine alkaloids (PAs): open-chain diester and monoester. However, the pharmacokinetics of these two types of PAs in rats have not been reported.… read more here.
Keywords: pharmacokinetic study; study two; comparative pharmacokinetic; pyrrolizidine alkaloids ... See more keywords
Comparative pharmacokinetic and bioequivalence of nine oral ivermectin formulations in dogs.
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DOI: 10.4142/jvs.25170
Abstract: Importance Canine heartworm disease remains a major global health issue. Despite the wide availability of ivermectin (IVM) formulations, pharmacokinetic and bioequivalence data are limited. Objective This study evaluated the pharmacokinetics and bioequivalence of eight oral… read more here.
Keywords: formulation; pharmacokinetic bioequivalence; nine oral; bioequivalence nine ... See more keywords