Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations
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DOI: 10.1002/ana.26561
Abstract: This study was undertaken to examine the comparative safety of antiseizure medication (ASM) monotherapy in pregnancy with respect to risk of major congenital malformations (MCMs), overall and by MCM subtype. read more here.
Keywords: antiseizure medication; safety antiseizure; comparative safety;
Comparative Safety and Pharmacokinetic Evaluation of Three Oral Selenium Compounds in Cancer Patients
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DOI: 10.1007/s12011-018-1501-0
Abstract: Selenium (Se) compounds have demonstrated anticancer properties in both preclinical and clinical studies, with particular promise in combination therapy where the optimal form and dose of selenium has yet to be established. In a phase… read more here.
Keywords: selenium compounds; safety pharmacokinetic; evaluation; selenium ... See more keywords
A comparative safety review of histone deacetylase inhibitors for the treatment of myeloma
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Drug Safety"
DOI: 10.1080/14740338.2019.1615051
Abstract: ABSTRACT Introduction: Dysregulation of histone deacetylase (HDAC) activity is an epigenetic hallmark of multiple myeloma (MM), leading to aberrant gene expression and cellular signaling in myeloma cell growth, survival and resistance to therapy. Hyper-methylation at… read more here.
Keywords: comparative safety; safety; myeloma; histone deacetylase ... See more keywords
Long‐term comparative safety analysis of the risks associated with adding or switching to a sulfonylurea as second‐line Type 2 diabetes mellitus treatment in a US veteran population
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DOI: 10.1111/dme.13839
Abstract: To examine the risks of all‐cause mortality and cardiovascular events associated with adding vs switching to second‐line therapies in a comparative safety study of people with Type 2 diabetes mellitus. read more here.
Keywords: associated adding; type diabetes; diabetes mellitus; adding switching ... See more keywords
Comparative safety of dipeptidyl peptidase‐4 inhibitors and sulfonylureas among frail older adults
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DOI: 10.1111/jgs.17371
Abstract: Studies comparing dipeptidyl peptidase‐4 inhibitors (DPP4Is) to sulfonylureas (SUs) are unavailable for frail older adults, especially nursing home (NH) residents. We examined the effects of DPP4Is versus SUs on severe adverse glycemic events, cardiovascular events,… read more here.
Keywords: peptidase inhibitors; frail older; dipeptidyl peptidase; older adults ... See more keywords
Comparative safety of sulfonylureas among U.S. nursing home residents
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DOI: 10.1111/jgs.18160
Abstract: The comparative safety of sulfonylureas (SUs) in nursing home (NH) residents remains understudied despite widespread use. We compared the effects of three SU medications and initial SU doses on adverse glycemic and cardiovascular events among… read more here.
Keywords: nursing home; safety sulfonylureas; home residents; comparative safety ... See more keywords
Reader response: Comparative safety and efficacy of combined IVT and MT with direct MT in large vessel occlusion
Sign Up to like & getrecommendations! Published in 2018 at "Neurology"
DOI: 10.1212/wnl.0000000000006652
Abstract: We support the findings of Goyal et al.,1 which showed that IV thrombolysis pretreatment improves outcomes in patients with large vessel occlusion (LVO) undergoing mechanical thrombectomy. We agree that reasons may include protection from infarct… read more here.
Keywords: comparative safety; response comparative; vessel occlusion; large vessel ... See more keywords