Coagulant Effect and Tolerability of Yeast-Produced Recombinant Batroxobin in Healthy Adult Subjects
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DOI: 10.1007/s40261-018-0673-x
Abstract: Background and ObjectiveBatroxobin, a snake venom thrombin-like enzyme, converts fibrinogen into fibrin by cleaving fibrinopeptide A. It is used for hemostasis; however, the supply of native batroxobin is limited. Therefore, we developed a recombinant batroxobin… read more here.
Keywords: recombinant batroxobin; group; study; compared placebo ... See more keywords
Safety and Efficacy of Ubrogepant for the Acute Treatment of Episodic Migraine: A Meta-Analysis of Randomized Clinical Trials
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DOI: 10.1007/s40263-020-00715-7
Abstract: Background Ubrogepant is a small molecular calcitonin gene–related peptide receptor antagonist that is used for the acute treatment of migraine. Objective The aim was to conduct a meta-analysis to systematically evaluate the efficacy and safety… read more here.
Keywords: episodic migraine; migraine; treatment; randomized clinical ... See more keywords
Evaluation of Individual Items of the Patient Health Questionnaire (PHQ-9) and Montgomery-Asberg Depression Rating Scale (MADRS) in Adults with Treatment-Resistant Depression Treated with Esketamine Nasal Spray Combined with a New Oral Antidepressant
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DOI: 10.1007/s40263-022-00916-2
Abstract: The objective of this study was to determine which symptoms measured by the Patient Health Questionnaire (PHQ-9) and Montgomery-Asberg Depression Rating Scale (MADRS) improve in those treated with esketamine nasal spray in combination with oral… read more here.
Keywords: placebo plus; treated esketamine; phq; esketamine plus ... See more keywords
Atorvastatin Versus Placebo for Prostate Cancer Before Radical Prostatectomy-A Randomized, Double-blind, Placebo-controlled Clinical Trial.
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DOI: 10.1016/j.eururo.2018.06.037
Abstract: We tested whether intervention with atorvastatin affects the prostate beneficially compared with placebo in men with prostate cancer in a randomized clinical trial. A total of 160 statin-naïve prostate cancer patients scheduled for radical prostatectomy… read more here.
Keywords: placebo; compared placebo; atorvastatin; prostate cancer ... See more keywords
A systematic review and network meta-analysis comparing treatments for faecal incontinence.
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DOI: 10.1016/j.ijsu.2019.04.007
Abstract: BACKGROUND Although numerous treatments exist for fecal incontinence (FI), no consensus exists on the best treatment strategy. The aim was to review the literature and to compare the clinical outcomes and effectiveness of treatments available… read more here.
Keywords: faecal incontinence; comparing treatments; incontinence; compared placebo ... See more keywords
Mediators of youth anxiety outcomes 3 to 12 years after treatment.
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DOI: 10.1016/j.janxdis.2020.102188
Abstract: OBJECTIVE Test changes in perceived coping efficacy, negative self-statements, and interpretive biases to threat during treatment as potential mediators of the relationship between randomly assigned treatment conditions and long-term anxiety follow-ups. Age at randomization was… read more here.
Keywords: intervention; anxiety; treatment; anxiety outcomes ... See more keywords
Omega-3-polyunsatured fatty acids (O3PUFAs), compared to placebo, reduced symptoms of occupational burnout and lowered morning cortisol secretion
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DOI: 10.1016/j.psyneuen.2019.104384
Abstract: BACKGROUND Occupational burnout is both a serious health concern at both public and individual levels. Treatment options are psychopharmacological, psychological and physical activity-related interventions. Here, we tested whether, compared to placebo, omega-3-polyunsaturated fatty acids (O3PUFAs)… read more here.
Keywords: fatty acids; compared placebo; morning; placebo ... See more keywords
Morphine compared to placebo for procedural pain in preterm infants: safety, efficacy and equipoise
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DOI: 10.1038/s41372-019-0476-9
Abstract: Among nonventilated preterm infants, who are less than 32 weeks of gestation or with birth weight less than 1501 g, undergoing an eye examination to detect retinopathy of prematurity (ROP) or heel lancing, will a… read more here.
Keywords: morphine compared; efficacy; compared placebo; preterm infants ... See more keywords
O06 Improvements in pain, function and health status with subcutaneous tanezumab compared with placebo in patients with OA: pooled analysis of two randomized controlled trials
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DOI: 10.1093/rheumatology/keaa110.005
Abstract: Osteoarthritis (OA) causes pain, disability and impaired quality of life. Tanezumab, a monoclonal antibody against nerve growth factor, is in development for the management of OA pain. Two randomised, placebo-controlled studies with a primary aim… read more here.
Keywords: week; tanezumab; group; study ... See more keywords
A14253 Anti Hypertensive Effect of Garcinia mangostana Linn extract in High Risk Framingham Score's Patient
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DOI: 10.1097/01.hjh.0000548927.99911.18
Abstract: Objectives: this study was to examine the antihypertensive effects of Garcinia mangostana Linn extract consumption in humans Methods: A randomized, Single-blind, placebo-controlled clinical trial was conducted in 66 pre- and mildly hypertensive adults which were… read more here.
Keywords: mangostana linn; compared placebo; garcinia mangostana; linn extract ... See more keywords
The Comparative Effectiveness of Vasoactive Treatments for Hepatorenal Syndrome: A Systematic Review and Network Meta-Analysis*
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DOI: 10.1097/ccm.0000000000005595
Abstract: OBJECTIVE: Hepatorenal syndrome (HRS) is associated with high rates of morbidity and mortality. Evidence examining commonly used drug treatments remains uncertain. We assessed the comparative effectiveness of inpatient treatments for HRS by performing a network… read more here.
Keywords: hrs reversal; compared placebo; analysis; hepatorenal syndrome ... See more keywords