Anti-apoptotic activity of ETB receptor agonist, IRL-1620, protects neural cells in rats with cerebral ischemia
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DOI: 10.1038/s41598-019-46203-x
Abstract: Endothelin-B receptor agonist, IRL-1620, provides significant neuroprotection following cerebral ischemia in rats. Whether this neuroprotection is due to inhibition of apoptosis is unknown. IRL-1620-treated rats following permanent middle cerebral artery occlusion (MCAO) showed significant improvement… read more here.
Keywords: compared vehicle; vehicle; irl 1620; cerebral ischemia ... See more keywords
THU0046 Small molecule inhibitor of the wnt pathway (SM04755) as a potential topical treatment for psoriasis
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DOI: 10.1136/annrheumdis-2018-eular.4752
Abstract: Background Psoriasis (PSO) is an autoimmune disease, causing patches of thick, inflamed, scaly skin due to excessive proliferation of skin cells1. Wnt signalling plays an important role in PSO, regulating inflammation and keratinocyte proliferation. SM04755,… read more here.
Keywords: compared vehicle; sm04755; samumed llc; vehicle ... See more keywords
Abstract WP161: Sovateltide Promotes Regeneration and Functional Recovery of Ischemic Brain by Improving Mitochondrial Function
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DOI: 10.1161/str.51.suppl_1.wp161
Abstract: Mitochondrial dysfunction is associated with cerebral ischemic stroke. Sovateltide (IRL-1620; PMZ-1620) undergoing clinical trials (NCT04047563; NCT04046484) has been demonstrated, in preclinical studies, to provide recovery of brain functions when administered following acute cerebral ischemic stroke.… read more here.
Keywords: vehicle; compared vehicle; cerebral ischemic; sovateltide ... See more keywords
Isorhamnetin Reduces Glucose Level, Inflammation, and Oxidative Stress in High-Fat Diet/Streptozotocin Diabetic Mice Model
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DOI: 10.3390/molecules28020502
Abstract: Background: Isorhamnetin is a flavonoid that is found in medical plants. Several studies showed that isorhamnetin has anti-inflammatory and anti-obesity effects. This study aims to investigate the anti-diabetic effects of isorhamnetin in a high-fat diet… read more here.
Keywords: compared vehicle; diabetic mice; isorhamnetin; model ... See more keywords