Articles with "comparison kinase" as a keyword



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Comparison of the Kinase Profile of Midostaurin (Rydapt) with That of Its Predominant Metabolites and the Potential Relevance of Some Newly Identified Targets to Leukemia Therapy.

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Published in 2018 at "Biochemistry"

DOI: 10.1021/acs.biochem.8b00727

Abstract: The multitargeted protein kinase inhibitor midostaurin is approved for the treatment of both newly diagnosed FLT3-mutated acute myeloid leukemia (AML) and KIT-driven advanced systemic mastocytosis. AML is a heterogeneous malignancy, and investigational drugs targeting FLT3… read more here.

Keywords: profile midostaurin; kinase; midostaurin metabolites; comparison kinase ... See more keywords