Comparison of the unfolding and oligomerization of human prion protein under acidic and neutral environments by molecular dynamics simulations
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DOI: 10.1016/j.cplett.2018.07.014
Abstract: Abstract Aggregation of the misfolded scrapie prion protein (PrPSc) is known to cause neurodegenerative diseases. In this paper, we have investigated the stability of PrPC by combining coarse-grained model and all-atom molecular simulations. Our results… read more here.
Keywords: oligomerization human; prion; comparison unfolding; unfolding oligomerization ... See more keywords