Dopamine compartmentalization, selective dopaminergic vulnerabilities in Parkinson's disease and therapeutic opportunities
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.707
Abstract: Progressive depletion of selected dopamine neurons is central to much Parkinson's disease (PD) disability. Although symptomatic treatments can ameliorate the disabilities that this neuronal depletion causes, no current strategy is documented to slow these losses.… read more here.
Keywords: selective dopaminergic; compartmentalization; compartmentalization selective; parkinson disease ... See more keywords
Compartmentalization and Selective Tagging for Disposal of Misfolded Glycoproteins.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2019.04.012
Abstract: The ability of mammalian cells to correctly identify and degrade misfolded secretory proteins, most of them bearing N-glycans, is crucial for their correct function and survival. An inefficient disposal mechanism results in the accumulation of… read more here.
Keywords: selective tagging; disposal misfolded; compartmentalization selective; disposal ... See more keywords