DNA Compatible Intermolecular Wittig Olefination for the Construction of α, β-Unsaturated Carbonyl Compounds.
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DOI: 10.1021/acs.orglett.0c01215
Abstract: A robust DNA-compatible Wittig reaction mediated by PPh2CH3 has been validated for DNA-conjugated α-chloroacetamides with aldehydes and, alternatively, DNA-conjugated aldehydes with α-halo acetamides or ketones. Further, 2-aminopyridines were acylated with α-chloroacetyl chloride and then reacted… read more here.
Keywords: dna compatible; carbonyl compounds; compatible intermolecular; unsaturated carbonyl ... See more keywords