Water-Compatible Synthesis of 2-Trifluoromethyl-1,3-Dioxanes
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201801367
Abstract: A water-compatible method for the diastereoselective synthesis of 2-trifluormethyl-1,3-dioxanes is described. The reaction proceeds under mild reaction conditions using simple inorganic bases; it has a very good substrate scope and can be performed with different… read more here.
Keywords: water; water compatible; synthesis trifluoromethyl; trifluoromethyl dioxanes ... See more keywords
DNA-Compatible Synthesis of α,β-Epoxyketones for DNA-Encoded Chemical Libraries.
Sign Up to like & getrecommendations! Published in 2021 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.1c00567
Abstract: As a powerful platform in drug discovery, the DNA-encoded chemical library technique enables the generation of numerous chemical members with high structural diversity. Epoxides widely exist in a variety of approved drugs and clinical candidates,… read more here.
Keywords: dna; dna encoded; dna compatible; compatible synthesis ... See more keywords