Compensatory evolution of chromosomes and plasmids counteracts the plasmid fitness cost
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DOI: 10.1002/ece3.70121
Abstract: Abstract Plasmids incur a fitness cost that has the potential to restrict the dissemination of resistance in bacterial pathogens. However, bacteria can overcome this disadvantage by compensatory evolution to maintain their resistance. Compensatory evolution can… read more here.
Keywords: evolution; fitness cost; chromosomes plasmids; compensatory evolution ... See more keywords
Nuclear compensatory evolution driven by mito-nuclear incompatibilities
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2411672121
Abstract: Significance Understanding how nuclear and mitochondrial genomes coevolve is critical for elucidating organismal resilience and adaptation. This study explores how mismatches between these interacting genomes impact substitutions, shedding light on nuclear compensation—a process where deleterious… read more here.
Keywords: evolution driven; driven mito; nuclear compensatory; nuclear incompatibilities ... See more keywords
Epistasis-mediated compensatory evolution in a fitness landscape with adaptational tradeoffs
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2422520122
Abstract: The evolutionary adaptation of an organism to a stressful environment often comes at the cost of reduced fitness. For example, resistance to antimicrobial drugs frequently reduces growth rate in the drug-free environment. This cost can… read more here.
Keywords: evolution; fitness; resistance; fitness landscape ... See more keywords
Compensatory Evolution Following Deleterious Episodes of GC-biased Gene Conversion in Rodents
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DOI: 10.1093/molbev/msaf168
Abstract: GC-biased gene conversion (gBGC) is a widespread evolutionary force associated with meiotic recombination that favours the accumulation of deleterious AT to GC substitutions in proteins, moving them away from their fitness optimum. In many mammals… read more here.
Keywords: biased gene; evolution; gene conversion; compensatory evolution ... See more keywords
Evidence for compensatory evolution within pleiotropic regulatory elements
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DOI: 10.1101/2024.01.10.575014
Abstract: Pleiotropy, measured as expression breadth across tissues, is one of the best predictors for protein sequence and expression conservation. In this study, we investigated its effect on the evolution of cis-regulatory elements (CREs). To this… read more here.
Keywords: regulatory elements; pleiotropic cres; conservation; evolution within ... See more keywords
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity.
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DOI: 10.1126/science.adv0657
Abstract: Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such complexes and threaten their essential functions remains unexplored. To investigate… read more here.
Keywords: hoap; multiprotein complex; multiprotein; compensatory evolution ... See more keywords