Structural Basis for Binding of Potassium-Competitive Acid Blockers to the Gastric Proton Pump.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00338
Abstract: As specific inhibitors of the gastric proton pump, responsible for gastric acidification, K+-competitive acid blockers (P-CABs) have recently been utilized in the clinical treatment of gastric acid-related diseases in Asia. However, as these compounds have… read more here.
Keywords: acid blockers; proton pump; gastric proton; competitive acid ... See more keywords
Vonoprazan: A New Potassium-Competitive Acid Blocker
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Pharmacy Technology"
DOI: 10.1177/87551225231166531
Abstract: Objective: To review the safety, efficacy, and tolerability of vonoprazan for the treatment of Helicobacter pylori infection in adults. Data Sources: A literature search was performed through PubMed using the following key terms: vonoprazan, Voquezna,… read more here.
Keywords: acid; competitive acid; acid blocker; potassium competitive ... See more keywords
Novel Potassium-Competitive Acid Blocker, Tegoprazan, Protects Against Colitis by Improving Gut Barrier Function
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.870817
Abstract: Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder characterized by prolonged inflammation of the gastrointestinal tract. IBD can result from gut barrier dysfunction, altered gut microbiota, and abnormal intestinal immunity induced by environmental factors… read more here.
Keywords: acid blocker; tegoprazan; acid; competitive acid ... See more keywords
Is a Potassium-Competitive Acid Blocker Truly Superior to Proton Pump Inhibitors in Terms of Helicobacter pylori Eradication?
Sign Up to like & getrecommendations! Published in 2021 at "Gut and liver"
DOI: 10.5009/gnl20242
Abstract: Vonoprazan (VPZ), a new potassium-competitive acid blocker, has been approved and used for Helicobacter pylori eradication in Japan. To date, many studies, as well as several systematic reviews and meta-analyses (MAs), have compared VPZ-based 7-day… read more here.
Keywords: competitive acid; based triple; potassium competitive; triple therapy ... See more keywords