Optimizing acid-related disease management: insights into potassium-competitive acid blockers and proton pump inhibitors
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DOI: 10.1007/s00228-025-03912-9
Abstract: This narrative review evaluates the clinical value of key globally marketed potassium-competitive acid blockers (P-CABs) for acid-related diseases (ARDs) based on current evidence-based medical research to inform clinical practice. We compare P-CABs and proton pump… read more here.
Keywords: acid related; proton pump; acid blockers; competitive acid ... See more keywords
Effects of Tegoprazan, Potassium-Competitive Acid Blocker, on the Gastric Emptying and Postprandial Symptoms in Healthy Humans
Sign Up to like & getrecommendations! Published in 2024 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-024-08714-0
Abstract: Proton pump inhibitors are potent gastric acid inhibitors. However, they may worsen symptoms such as postprandial fullness and early satiation by reducing gastric emptying (GE). This study aims to evaluate the effects of tegoprazan, a… read more here.
Keywords: gastric emptying; effects tegoprazan; acid blocker; competitive acid ... See more keywords
Potassium-competitive Acid Blockers: Current Clinical Use and Future Developments
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DOI: 10.1007/s11894-024-00939-3
Abstract: Acid suppression with proton pump inhibitors (PPIs) represents the standard of care in the treatment of acid-related diseases. However, despite their effectiveness, PPIs display some intrinsic limitations, which underlie the unmet clinical needs that have… read more here.
Keywords: acid blockers; acid suppression; competitive acid; acid ... See more keywords
Structural Basis for Binding of Potassium-Competitive Acid Blockers to the Gastric Proton Pump.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00338
Abstract: As specific inhibitors of the gastric proton pump, responsible for gastric acidification, K+-competitive acid blockers (P-CABs) have recently been utilized in the clinical treatment of gastric acid-related diseases in Asia. However, as these compounds have… read more here.
Keywords: acid blockers; proton pump; gastric proton; competitive acid ... See more keywords
Proton pump inhibitors and potassium competitive acid blockers decrease pembrolizumab efficacy in patients with metastatic urothelial carcinoma
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DOI: 10.1038/s41598-024-53158-1
Abstract: We elucidated the efficacy of gut microbiome–altering drugs on pembrolizumab efficacy in patients with metastatic urothelial carcinoma (mUC). Clinical data were analyzed retrospectively from 133 patients with mUC who received second-line pembrolizumab therapy between January… read more here.
Keywords: proton pump; efficacy; acid blockers; competitive acid ... See more keywords
Efficacy and safety of potassium-competitive acid inhibitors in the treatment of gastroesophageal reflux: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2024 at "Scandinavian Journal of Gastroenterology"
DOI: 10.1080/00365521.2024.2349638
Abstract: Abstract Background Gastroesophageal reflux disease (GERD) is a common disease caused by reflux of gastric contents to the esophagus. Proton-pump inhibitors (PPIs) are recommended as a first-line therapy to treat GERD. Recently, the potassium-competitive acid… read more here.
Keywords: analysis; acid inhibitors; competitive acid; safety ... See more keywords
Vonoprazan: A New Potassium-Competitive Acid Blocker
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DOI: 10.1177/87551225231166531
Abstract: Objective: To review the safety, efficacy, and tolerability of vonoprazan for the treatment of Helicobacter pylori infection in adults. Data Sources: A literature search was performed through PubMed using the following key terms: vonoprazan, Voquezna,… read more here.
Keywords: acid; competitive acid; acid blocker; potassium competitive ... See more keywords
Network Meta-Analysis of Comparing Different Dosages of Potassium-Competitive Acid Blocker With Proton-Pump Inhibitor in Acid-Related Disorders
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DOI: 10.14309/ctg.0000000000000776
Abstract: INTRODUCTION: Potassium-competitive acid blockers have emerged as a promising treatment of acid-related disorders. However, the optimal dosage for maximizing their efficacy remains unclear. The aim of this network meta-analysis was to compare the efficacy and… read more here.
Keywords: acid related; sucra value; competitive acid; acid ... See more keywords
Novel Potassium-Competitive Acid Blocker, Tegoprazan, Protects Against Colitis by Improving Gut Barrier Function
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.870817
Abstract: Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder characterized by prolonged inflammation of the gastrointestinal tract. IBD can result from gut barrier dysfunction, altered gut microbiota, and abnormal intestinal immunity induced by environmental factors… read more here.
Keywords: acid blocker; tegoprazan; acid; competitive acid ... See more keywords
Pharmacokinetics, mass balance, and metabolism of the novel potassium-competitive acid blocker JP-1366 in healthy Chinese adults following a single oral dose of [14C]JP-1366
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2025.1701581
Abstract: Introduction JP-1366 (zastaprazan), a novel potassium-competitive acid blocker (P-CAB), was approved in South Korea in 2024 for treating erosive gastroesophageal reflux disease (GERD). This mass balance study characterized the pharmacokinetics, metabolism, excretion, and safety profile… read more here.
Keywords: dose; acid blocker; metabolism; competitive acid ... See more keywords
Advances in Gastroesophageal Reflux Disease Management: Exploring the Role of Potassium-Competitive Acid Blockers and Novel Therapies
Sign Up to like & getrecommendations! Published in 2025 at "Pharmaceuticals"
DOI: 10.3390/ph18050699
Abstract: Gastroesophageal reflux disease (GERD) is a prevalent chronic gastrointestinal disorder that affects a substantial proportion of the global population. It is characterized by the extensive backward flow of stomach contents into the esophagus, leading to… read more here.
Keywords: gastroesophageal reflux; acid blockers; reflux disease; competitive acid ... See more keywords