Competitive Affinity-Based Protein Profiling Reveals Potential Antifungal Targets of 1,2,3-Triazole Hydrazide in Fusarium graminearum.
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DOI: 10.1021/acs.jafc.4c12342
Abstract: In previous research, 1,2,3-triazole hydrazide NAU-6ad exhibited remarkable broad-spectrum antifungal activity. However, the specific targets of NAU-6ad remained unknown. Initially, we excluded three targets─succinate dehydrogenase, laccase, and ergosterol synthase─commonly associated with hydrazide derivatives mentioned in… read more here.
Keywords: affinity based; competitive affinity; nau 6ad; graminearum ... See more keywords
Competitive affinity-based proteome profiling and imaging to reveal potential cellular targets of betulinic acid.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc04190j
Abstract: Betulinic acid (BA), a pentacyclic triterpenoid natural product, has received considerable attention owing to the broad spectrum of biological activities such as anti-HIV, anti-inflammatory, and especially, antitumor. Despite numerous studies on the antitumor mechanisms over… read more here.
Keywords: potential cellular; competitive affinity; proteome profiling; betulinic acid ... See more keywords