Competitive binding assays for measuring the binding affinity of thyroid-disrupting chemicals for integrin αvβ3.
Sign Up to like & getrecommendations! Published in 2020 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2020.126034
Abstract: Some thyroid-disrupting chemicals (TDCs) affect thyroid function by activating the pathways mediated by a typical thyroid hormone (TH) membrane receptor, integrin αvβ3. The present study introduces improved competitive binding assays for the rapid and sensitive… read more here.
Keywords: binding assay; radioligand competitive; binding; competitive binding ... See more keywords
Prototype Digital Lateral Flow Sensor Using Impact Electrochemistry in a Competitive Binding Assay.
Sign Up to like & getrecommendations! Published in 2022 at "ACS sensors"
DOI: 10.1021/acssensors.2c00728
Abstract: This work demonstrates a lateral flow assay concept on the basis of stochastic-impact electrochemistry. To this end, we first elucidate requirements to employ silver nanoparticles as redox-active labels. Then, we present a prototype that utilizes… read more here.
Keywords: impact electrochemistry; lateral flow; electrochemistry; competitive binding ... See more keywords
Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26653-6
Abstract: The pluripotency transcription factor SOX2 is essential for the maintenance of glioblastoma stem cells (GSC), which are thought to underlie tumor growth, treatment resistance, and recurrence. To understand how SOX2 is regulated in GSCs, we… read more here.
Keywords: binding ligases; wwp2; sox2; ligases trim26 ... See more keywords
Competitive Binding of Transcription Factors Underlies Flexibility of T Peripheral Helper Cells and T Follicular Helper Cells in SLE.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1093/rheumatology/keac112
Abstract: OBJECTIVE Peripheral helper T (Tph) cells interact with B cells and promote immune responses at sites of ectopic lymphoid structures (ELSs). To assess the characteristics of Tph cells, we investigated the phenotype of T helper… read more here.
Keywords: tph cells; peripheral helper; helper; helper cells ... See more keywords
A Novel Competitive Binding Screening Assay Reveals Sennoside B as a Potent Natural Product Inhibitor of TNF-α
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9091250
Abstract: Natural products (NPs) have played a significant role in drug discovery for diverse diseases, and numerous attempts have been made to discover promising NP inhibitors of tumor necrosis factor α (TNF-α), a major therapeutic target… read more here.
Keywords: inhibitor; inhibitor tnf; competitive binding; screening assay ... See more keywords