The development and controversy of competitive endogenous RNA hypothesis in non-coding genes
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-020-03889-2
Abstract: As a momentous post-transcriptional regulator, microRNAs (miRNAs) are attracting more and more attention. The classical miRNAs regulated mechanism shows it binds to the targets’ 3′UTR thus play the role in post-transcription. Meanwhile, single miRNA can… read more here.
Keywords: controversy; competitive endogenous; non coding; hypothesis ... See more keywords
Downregulated USP3 mRNA functions as a competitive endogenous RNA of SMAD4 by sponging miR-224 and promotes metastasis in colorectal cancer
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04368-3
Abstract: Increasing evidence shows that competitive endogenous RNAs (ceRNAs) can affect the expression of other transcripts by sequestering common microRNAs (miRNAs), and participate in tumourigenesis. As a potent tumour suppressor in colorectal cancer (CRC), SMAD4 is… read more here.
Keywords: smad4; mir 224; colorectal cancer; competitive endogenous ... See more keywords
Role of exosomal competitive endogenous RNA (ceRNA) in diagnosis and treatment of malignant tumors
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2073130
Abstract: ABSTRACT Malignant tumors are a threat to human health, thus it is critical to better understand the mechanism of tumor occurrence and development and to find key therapeutic targets. Competitive endogenous RNA (ceRNA) is a… read more here.
Keywords: competitive endogenous; malignant tumors; cerna diagnosis; rna ... See more keywords
Identification of Novel Multi-Omics Expression Landscapes and Meta-Analysis of Landscape-Based Competitive Endogenous RNA Networks in ALDH+ Lung Adenocarcinoma Stem Cells
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/9545609
Abstract: ALDH+ H1975 lung adenocarcinoma stem cells (LSCs) are a rare cell population identified in lung adenocarcinoma (LUAD). LSCs can self-renew, drive tumor initiation, growth, metastasis, and recurrence and are also the predominant cause of poor… read more here.
Keywords: competitive endogenous; meta analysis; lung adenocarcinoma; adenocarcinoma stem ... See more keywords
Gain of chromosome 1q perturbs a competitive endogenous RNA network to promote melanoma metastasis.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-0283
Abstract: Somatic copy number alterations (CNA) promote cancer, but the underlying driver genes may not be comprehensively identified if only the functions of the encoded proteins are considered. mRNAs can act as competitive endogenous RNAs (ceRNA)… read more here.
Keywords: metastasis; competitive endogenous; melanoma metastasis; chromosome ... See more keywords
Tumor infiltrating lymphocytes associated competitive endogenous RNA networks as predictors of outcome in hepatic carcinoma based on WGCNA analysis
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0254829
Abstract: Background The important regulatory role of competitive endogenous RNAs (ceRNAs) in hepatocellular carcinoma (HCC) has been confirmed. Tumor infiltrating lymphocytes (TILs) are of great significance to tumor outcome and prognosis. This study will systematically analyze… read more here.
Keywords: hcc; analysis; competitive endogenous; model ... See more keywords
Competitive endogenous RNA networks: integrated analysis of non-coding RNA and mRNA expression profiles in infantile hemangioma
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.23946
Abstract: Infantile hemangioma (IH) is the most common vascular tumour in infants. The pathogenesis of IH is complex and poorly understood. Therefore, achieving a deeper understanding of IH pathogenesis is of great importance. Here, we used… read more here.
Keywords: ontology; expression profiles; rna; competitive endogenous ... See more keywords
Integrated Analysis of Competitive Endogenous RNA Networks in Acute Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.833545
Abstract: Background: Acute ischemic stroke (AIS) is a severe neurological disease with complex pathophysiology, resulting in the disability and death. The goal of this study is to explore the underlying molecular mechanisms of AIS and search… read more here.
Keywords: ischemic stroke; acute ischemic; endogenous rna; competitive endogenous ... See more keywords
Construction, bioinformatics analysis, and validation of competitive endogenous RNA networks in ulcerative colitis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.951243
Abstract: Background: Ulcerative colitis (UC) is a common chronic disease of the digestive system. Recently, competitive endogenous RNAs (ceRNAs) have been increasingly used to reveal key mechanisms for the pathogenesis and treatment of UC. However, the… read more here.
Keywords: network; competitive endogenous; cerna network; bioinformatics analysis ... See more keywords
Construction of a Competitive Endogenous RNA Network and Identification of Potential Regulatory Axis in Gastric Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.00912
Abstract: Background: Increasing studies has found that long non-coding RNAs (lncRNAs) play critical roles in carcinogenesis, but the underlying mechanisms remain unclear. The aim of this study is to construct a competitive endogenous RNA (ceRNA) network… read more here.
Keywords: adamts9 as2; network; rna; competitive endogenous ... See more keywords
Multi-Omics Integration Reveals a Competitive Endogenous RNAs Network for the Identification of Progression Biomarkers and the Stratification of Patients Diagnosed With Nephroblastoma
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.00444
Abstract: Specific types of nephroblastoma (Wilms' tumor, WT) are known to associate with poor overall survival. Emerging experimental evidence has demonstrated that competitive endogenous RNA (ceRNA) networks have important roles in regulating cancer occurrence, but the… read more here.
Keywords: network; multi omics; cerna; competitive endogenous ... See more keywords