Competitive inhibition by NAG-1/GDF-15 NLS peptide enhances its anti-cancer activity.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.08.090
Abstract: Non-steroidal anti-inflammatory drug activated gene-1 (NAG-1), also known as growth differentiation factor 15 (GDF15), is a TGF-β (transforming growth factor beta) superfamily protein with a distinctive secretion pathway. NAG-1 is associated with multiple diseases including… read more here.
Keywords: peptide; nag; competitive inhibition; cancer ... See more keywords
IDH Mutation, Competitive Inhibition of FTO, and RNA Methylation.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.04.001
Abstract: A recent report published in Cancer Cell used elaborate in vitro and in vivo systems to link FTO expression to the pathogenesis of acute myeloid leukemia (AML) (Li et al., 2017). The N6-methyladenosine (m6A) RNA… read more here.
Keywords: competitive inhibition; inhibition fto; rna; fto rna ... See more keywords
Development of a competitive inhibition kinetic ELISA to determine the inhibition constant (Ki) of monoclonal antibodies.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of immunological methods"
DOI: 10.1016/j.jim.2021.113042
Abstract: Antibody-antigen interactions are mediated by the same molecular recognition mechanisms as those of an enzyme and its substrate. On this basis, we developed a competitive inhibition kinetic ELISA to measure monoclonal antibody (mAb) inhibition constants.… read more here.
Keywords: mab inhibition; competitive inhibition; inhibition; kinetic elisa ... See more keywords
Fiber optic particle plasmon resonance immunosensor for rapid and sensitive detection of methamphetamine based on competitive inhibition
Sign Up to like & getrecommendations! Published in 2020 at "Microchemical Journal"
DOI: 10.1016/j.microc.2020.105026
Abstract: Abstract We report the study of methamphetamine (MA) sensing in urine samples using fiber optic particle plasmon resonance (FOPPR) biosensor. This approach is intended for on-site analysis of low-molecular-weight compounds. High sensitivity detection of MA… read more here.
Keywords: detection; competitive inhibition; particle plasmon; fiber optic ... See more keywords
Temperature-Responsive Competitive Inhibition of CRISPR-Cas9.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.11.016
Abstract: CRISPR-Cas immune systems utilize RNA-guided nucleases to protect bacteria from bacteriophage infection. Bacteriophages have in turn evolved inhibitory "anti-CRISPR" (Acr) proteins, including six inhibitors (AcrIIA1-AcrIIA6) that can block DNA cutting and genome editing by type… read more here.
Keywords: crispr; dna; competitive inhibition; crispr cas9 ... See more keywords
Mechanism of surface plasmon resonance sensing by indirect competitive inhibition immunoassay using Au nanoparticle labeled antibody.
Sign Up to like & getrecommendations! Published in 2017 at "Talanta"
DOI: 10.1016/j.talanta.2017.05.003
Abstract: We investigated the use of a surface plasmon resonance (SPR) biosensor using an antibody (Ab) labeled with Au-nanoparticle (Ab-AuNP conjugate). As clenbuterol is a small molecule, an indirect competitive inhibition immunoassay was used. The SPR… read more here.
Keywords: inhibition immunoassay; indirect competitive; competitive inhibition; surface plasmon ... See more keywords
Transient Competitive Inhibition Bypasses the Binding Site Barrier to Improve Tumor Penetration of Trastuzumab and Enhance T-DM1 Efficacy
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Research"
DOI: 10.1158/0008-5472.can-20-3822
Abstract: This study describes the development of a transient competitive inhibition strategy that enhances the tumor penetration and efficacy of anticancer antibodies. Poor penetration of mAbs in solid tumors is explained, in part, by the binding… read more here.
Keywords: transient competitive; efficacy; competitive inhibition; tumor ... See more keywords
Competitive Inhibition of Mammalian Hyaluronidase by Tomato Saponin, Esculeoside A
Sign Up to like & getrecommendations! Published in 2018 at "Natural Product Communications"
DOI: 10.1177/1934578x1801301112
Abstract: Esculeoside A, a glycoside of spirosolane-type, is identified as a major component in ripe tomato fruits. Our previous study showed that esculeoside A inhibited hyaluronidase activity in vitro and ameliorated experimental dermatitis in vivo. The… read more here.
Keywords: mammalian hyaluronidase; hyaluronidase; competitive inhibition; inhibition ... See more keywords