Abstract 6489: Paradoxical activation of kinases occurs directly with ATP-competitive kinase inhibitors and is observable biochemically at physiologically relevant drug concentrations
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DOI: 10.1158/1538-7445.am2024-6489
Abstract: We sought to screen all FDA approved, cancer-indicated, kinase targeting drugs using the gold standard radiometric biochemical activity assay (HotSpot) against the largest collection of kinases in the world (>100 drugs against 735 total kinases… read more here.
Keywords: atp competitive; kinase; activation; competitive kinase ... See more keywords