A novel preclinical model of RAF-independent MEK1 mutant tumors and its treatment with novel ATP competitive MEK inhibitor
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DOI: 10.1093/annonc/mdz268.085
Abstract: Abstract Background A subgroup of MEK1 mutations in human tumors were recently described as RAF- and phosphorylation independent and as insensitive to currently clinically used allosteric MEK inhibitors. We established a novel cell line that… read more here.
Keywords: inhibitor; mek inhibitor; atp competitive; mek ... See more keywords