Role of the Complement System in Chronic Central Serous Chorioretinopathy: A Genome-Wide Association Study
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Ophthalmology"
DOI: 10.1001/jamaophthalmol.2018.3190
Abstract: Importance To date, several targeted genetic studies on chronic central serous chorioretinopathy (cCSC) have been performed; however, unbiased genome-wide studies into the genetics of cCSC have not been reported. To discover new genetic loci associated… read more here.
Keywords: genome wide; chronic central; association; complement ... See more keywords
Impact of complement activation on clinical outcomes in multiple sclerosis
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51334
Abstract: We determined activation profiles of the classical and alternative complement pathway in 39 treatment‐naïve patients with early relapse‐onset MS. Plasma concentrations of complement fragments were unchanged in MS compared to 32 patients with non‐inflammatory neurological… read more here.
Keywords: impact complement; clinical outcomes; complement; activation ... See more keywords
Complement‐Opsonized NIR‐IIb Emissive Immunotracers for Dynamically Monitoring Neutrophils in Inflammation‐Related Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202203477
Abstract: Real‐time monitoring of neutrophil dynamics is crucial for timely diagnosis and effective treatment of inflammation‐related diseases, which requires a reliable tracer for in vivo tracking of neutrophils. However, immunotracers for neutrophils are extremely limited because… read more here.
Keywords: inflammation; iib emissive; complement; related diseases ... See more keywords
Hyper‐inflammation and complement in COVID‐19
Sign Up to like & getrecommendations! Published in 2023 at "American Journal of Hematology"
DOI: 10.1002/ajh.26746
Abstract: COVID‐19 is a complex disease manifesting in a broad severity spectrum and involving distinct organs and systems. Hyperinflammation, including complement over‐activation, has a pivotal role in severe COVID‐19 pathobiology, stimulating the inflammatory response, causing microangiopathy,… read more here.
Keywords: complement; hyper inflammation; covid; complement covid ... See more keywords
Paroxysmal nocturnal hemoglobinuria: Where we stand
Sign Up to like & getrecommendations! Published in 2023 at "American Journal of Hematology"
DOI: 10.1002/ajh.26832
Abstract: For the last 20 years, therapy of paroxysmal nocturnal hemoglobinuria (PNH) relied—up until recently—on antibody based terminal complement inhibitionon. PNH pathophysiology—a mutational defect leading to partial or complete absence of complement‐regulatory proteins on blood cells—leads to… read more here.
Keywords: hemoglobinuria stand; complement; nocturnal hemoglobinuria; paroxysmal nocturnal ... See more keywords
Paroxysmal nocturnal hemoglobinuria: Where are we going
Sign Up to like & getrecommendations! Published in 2023 at "American Journal of Hematology"
DOI: 10.1002/ajh.26882
Abstract: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare nonmalignant clonal hematological disorder that is characterized by a deficiency of the GPI‐linked complement regulators on the membrane of hematopoietic cells, which renders them susceptible to complement‐mediated damage.… read more here.
Keywords: hemoglobinuria going; complement; nocturnal hemoglobinuria; paroxysmal nocturnal ... See more keywords
Sustained inhibition of complement C1s with sutimlimab over 2 years in patients with cold agglutinin disease.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of hematology"
DOI: 10.1002/ajh.26965
Abstract: Cold agglutinin disease (CAD) is a rare, autoimmune, classical complement pathway (CP)-mediated hemolytic anemia. Sutimlimab selectively inhibits C1s of the C1 complex, preventing CP activation while leaving the alternative and lectin pathways intact. In Part… read more here.
Keywords: complement; agglutinin disease; sutimlimab; treatment ... See more keywords
A Randomized, First‐in‐Human, Healthy Volunteer Trial of sutimlimab, a Humanized Antibody for the Specific Inhibition of the Classical Complement Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1111
Abstract: Aberrant activation of the classical complement pathway is the common underlying pathophysiology of orphan diseases such as bullous pemphigoid, antibody‐mediated rejection of organ transplants, cold agglutinin disease, and warm autoimmune hemolytic anemia. Therapeutic options for… read more here.
Keywords: inhibition classical; sutimlimab humanized; complement pathway; classical complement ... See more keywords
Tumor‐shed antigen CA125 blocks complement‐mediated killing via suppression of C1q‐antibody binding
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201847707
Abstract: C1q‐engagement with IgG and IgM type antibodies is the initiating step of classical complement‐mediated immunity. The tumor shed antigen CA125 has been reported to have immunosuppressive effects on host tumor responses as well as commercially… read more here.
Keywords: ca125; antibody; c1q; complement ... See more keywords
Complement, complosome, and complotype: a perspective.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250042
Abstract: Recent rapid progress in key technological advances, including the broader accessibility of single cell 'omic' approaches, allowed immunologists to gain important novel insights into the contributions of individual immune cells in protective immunity and immunopathologies.… read more here.
Keywords: complosome complotype; complement; complement complosome; physiology ... See more keywords
HIV Tat causes synapse loss in a mouse model of HIV‐associated neurocognitive disorder that is independent of the classical complement cascade component C1q
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23511
Abstract: Microglial activation, increased proinflammatory cytokine production, and a reduction in synaptic density are key pathological features associated with HIV‐associated neurocognitive disorders (HAND). Even with combination antiretroviral therapy (cART), more than 50% of HIV‐positive individuals experience… read more here.
Keywords: hiv; complement; associated neurocognitive; tat ... See more keywords