Impact of complement activation on clinical outcomes in multiple sclerosis
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51334
Abstract: We determined activation profiles of the classical and alternative complement pathway in 39 treatment‐naïve patients with early relapse‐onset MS. Plasma concentrations of complement fragments were unchanged in MS compared to 32 patients with non‐inflammatory neurological… read more here.
Keywords: impact complement; clinical outcomes; complement; activation ... See more keywords
Effect of dipeptidyl peptidase‐4 inhibitors on complement activation
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3385
Abstract: Adverse activation of the complement cascade in the innate immune system appears to be involved in development of vascular complications in diabetes. Dipeptidyl peptidase‐4 (DPP‐4) is a cell surface serine protease expressed in a variety… read more here.
Keywords: peptidase inhibitors; effect dipeptidyl; activation; dipeptidyl peptidase ... See more keywords
Complement factor H protects mice from ischemic acute kidney injury but is not critical for controlling complement activation by glomerular IgM
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201747240
Abstract: Natural IgM binds to glomerular epitopes in several progressive kidney diseases. Previous work has shown that IgM also binds within the glomerulus after ischemia/reperfusion (I/R) but does not fully activate the complement system. Factor H… read more here.
Keywords: factor; igm; complement activation; injury ... See more keywords
Quantification of Porcine Complement Activation Fragment C3a by a Neoepitope-Based Enzyme-Linked Immunosorbent Assay.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1016-9_5
Abstract: Enzyme-linked immunosorbent assay (ELISA) enables fast and simple quantification of analytes in the pico- to nanogram range in complex samples. Here, we describe an ELISA for the detection of porcine C3a as a marker for… read more here.
Keywords: c3a; linked immunosorbent; immunosorbent assay; complement activation ... See more keywords
Analysis of Complement Activation by Nanoparticles.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7352-1_13
Abstract: The complement system is a group of proteins, which function in plasma to assist the innate immunity in rapid clearance of pathogens. The complement system also contributes to coordination of the adaptive immune response. Complement… read more here.
Keywords: analysis complement; complement system; complement; complement activation ... See more keywords
Complement activation, a threat to pregnancy
Sign Up to like & getrecommendations! Published in 2017 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-017-0645-x
Abstract: Pregnancy poses a challenge for the immune systems of placental mammals. As fetal tissues are semi-allogeneic and alloantibodies that commonly develop in the mother, the fetus and the placenta might be subject to complement-mediated immune… read more here.
Keywords: activation threat; pregnancy; complement; complement activation ... See more keywords
Complement activation in IgA nephropathy.
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in immunopathology"
DOI: 10.1007/s00281-021-00882-9
Abstract: IgA nephropathy pathogenesis is incompletely understood, and this limits the development of disease-specific biomarkers and effective therapies. Evidence of complement activity in IgA nephropathy is well established. However, a growing body of research indicates complement… read more here.
Keywords: iga; complement activation; iga nephropathy; complement activity ... See more keywords
Complement regulation and kidney diseases: recent knowledge of the double-edged roles of complement activation in nephrology
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Experimental Nephrology"
DOI: 10.1007/s10157-017-1405-x
Abstract: The complement activation system plays important roles to maintain homeostasis in the host and to fight foreign invaders to protect the host. Therefore, the complement system is considered a core part of innate immunity which… read more here.
Keywords: nephrology; complement; nephrology complement; complement activation ... See more keywords
Complement Activation in 22q11.2 Deletion Syndrome
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DOI: 10.1007/s10875-020-00766-x
Abstract: The 22q11.2 deletion syndrome (22q11.2 del), also known as DiGeorge syndrome, is a genetic disorder with an estimated incidence of 1:3000 to 1:6000 births. These patients may suffer from affection of many organ systems with… read more here.
Keywords: complement; complement activation; deletion syndrome; 22q11 deletion ... See more keywords
Formation of Protein Corona on Nanoparticle Affects Different Complement Activation Pathways Mediated by C1q
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DOI: 10.1007/s11095-019-2747-8
Abstract: As nanoparticles (NPs) are intravenously entering the bloodstream, proteins in the plasma can recognize and bind them to form a protein corona that affects how NPs are perceived by biological systems. The complement is an… read more here.
Keywords: complement; protein corona; activation; complement activation ... See more keywords
Coagulopathy, endothelial dysfunction, thrombotic microangiopathy and complement activation: potential role of complement system inhibition in COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-020-02297-z
Abstract: Coronavirus disease-2019 (COVID-19) is a rapidly evolving health crisis caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is a novel disease entity and we are in a learning phase with regards to… read more here.
Keywords: covid; complement; complement activation; complement system ... See more keywords