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   Articles with "complement activity" as a keyword



Complement activation in IgA nephropathy.

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recommendations! Published in 2021 at "Seminars in immunopathology"

DOI: 10.1007/s00281-021-00882-9

Abstract: IgA nephropathy pathogenesis is incompletely understood, and this limits the development of disease-specific biomarkers and effective therapies. Evidence of complement activity in IgA nephropathy is well established. However, a growing body of research indicates complement… read more here.

Keywords: iga; complement activation; iga nephropathy; complement activity ... See more keywords

Analyzing complement activity in the serum and body homogenates of different fish species, using rabbit and sheep red blood cells.

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recommendations! Published in 2018 at "Veterinary immunology and immunopathology"

DOI: 10.1016/j.vetimm.2018.03.008

Abstract: Alternative complement activity was determined in whole body homogenates (WBHs) and serum samples of different fish species, by measuring the amount of sample that induces 50% hemolysis of red blood cells using the ACH50 assay… read more here.

Keywords: red blood; activity; fish species; complement activity ... See more keywords
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Optimizing Complement Inhibitor Monitoring in PNH and Beyond

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recommendations! Published in 2024 at "Blood"

DOI: 10.1182/blood-2024-200838

Abstract: Introduction: There are now 6 FDA approved therapies for paroxysmal nocturnal hemoglobinuria (PNH). All are effective in controlling complement-mediated intravascular hemolysis (IVH) but associated with potential for breakthrough hemolysis (BTH). Differentiating pharmacokinetic (PK) from pharmacodynamic… read more here.

Keywords: complement activity; inhibition; pnh; inhibitor ... See more keywords

MASP3 Deficiency in Mice Reduces but Does Not Abrogate Alternative Pathway Complement Activity Due to Intrinsic Profactor D Activity.

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recommendations! Published in 2023 at "Journal of immunology"

DOI: 10.4049/jimmunol.2200932

Abstract: Complement factor D (FD) is a rate-limiting enzyme of the alternative pathway (AP). Recent studies have suggested that it is synthesized as an inactive precursor and that its conversion to enzymatically active FD is catalyzed… read more here.

Keywords: activity; complement activity; mice; masp3 ... See more keywords