IL‐1/IL‐1R signaling induced by all‐trans‐retinal contributes to complement alternative pathway activation in retinal pigment epithelium
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DOI: 10.1002/jcp.30103
Abstract: The underlying mechanisms of complement activation in Stargardt disease type 1 (STGD1) and age‐related macular degeneration (AMD) are not fully understood. Overaccumulation of all‐trans‐retinal (atRAL) has been proposed as the pathogenic factor in both diseases.… read more here.
Keywords: complement alternative; alternative pathway; rpe cells; activation ... See more keywords
Gene targeting as a therapeutic avenue in diseases mediated by the complement alternative pathway
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DOI: 10.1111/imr.13149
Abstract: The complement alternative pathway (AP) is implicated in numerous diseases affecting many organs, ranging from the rare hematological disease paroxysmal nocturnal hemoglobinuria (PNH), to the common blinding disease age‐related macular degeneration (AMD). Critically, the AP… read more here.
Keywords: targeting therapeutic; alternative pathway; gene targeting; complement alternative ... See more keywords
The complement alternative pathway and hemostasis
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DOI: 10.1111/imr.13150
Abstract: The complement and hemostatic systems are complex systems, and both involve enzymatic cascades, regulators, and cell components—platelets, endothelial cells, and immune cells. The two systems are ancestrally related and are defense mechanisms that limit infection… read more here.
Keywords: alternative pathway; complement; pathway hemostasis; complement alternative ... See more keywords
The potential role of complement alternative pathway activation in hypertensive renal damage
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DOI: 10.1177/15353702221091986
Abstract: Hypertensive renal damage is a common secondary kidney disease caused by poor control of blood pressure. Recent evidence has revealed abnormal activation of the complement alternative pathway (AP) in hypertensive patients and animal models and… read more here.
Keywords: complement alternative; renal damage; hypertensive renal; activation ... See more keywords