Complement blockade with eculizumab for treatment of severe Coronavirus Disease 2019 in pregnancy: A case series
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DOI: 10.1111/aji.13559
Abstract: We evaluated eculizumab, a complement protein C5 inhibitor, for treatment of severe COVID‐19 in pregnant and postpartum individuals. read more here.
Keywords: eculizumab treatment; complement; blockade eculizumab; complement blockade ... See more keywords
Targeted donor complement blockade after brain death prevents delayed graft function in a nonhuman primate model of kidney transplantation
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DOI: 10.1111/ajt.15777
Abstract: Delayed graft function (DGF) in renal transplant is associated with reduced graft survival and increased immunogenicity. The complement‐driven inflammatory response after brain death (BD) and posttransplant reperfusion injury play significant roles in the pathogenesis of… read more here.
Keywords: graft; complement; transplantation; function ... See more keywords
Complement blockade for TA-TMA: lessons learned from large pediatric cohort treated with eculizumab.
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DOI: 10.1182/blood.2019004218
Abstract: Overactivated complement is a high-risk feature in HSCT recipients with transplant associated thrombotic microangiopathy (TA-TMA), and untreated patients have dismal outcomes. We present our experience of 64 pediatric HSCT recipients with high risk TA-TMA and… read more here.
Keywords: high risk; hsct; eculizumab; tma ... See more keywords