Complement C3a receptor antagonist attenuates tau hyperphosphorylation via glycogen synthase kinase 3&bgr; signaling pathways
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2019.02.020
Abstract: ABSTRACT Neurofibrillary tangles aggregated from hyperphosphorylated tau protein are the main pathological feature of Alzheimer's disease (AD). Complement C3 (or C3a) is the core component of the complement system and is associated with AD pathological… read more here.
Keywords: receptor; c3a receptor; bgr; complement c3a ... See more keywords
Potent Thiophene Antagonists of Human Complement C3a Receptor with Anti-Inflammatory Activity.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00927
Abstract: Structure-activity relationships for a series of small-molecule thiophenes resulted in potent and selective antagonism of human Complement C3a receptor. The compounds are about 100-fold more potent than the most reported antagonist SB290157. A new compound… read more here.
Keywords: c3a; c3a receptor; activity; human complement ... See more keywords
The association between serum complement C3a and severity in patients with community-acquired pneumonia
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1034233
Abstract: Background A few studies found that the complement system may be involved in the onset and progression of community-acquired pneumonia (CAP). However, the role of the complement system in CAP was obscure. The goal of… read more here.
Keywords: complement; serum complement; cap; complement c3a ... See more keywords