Neuronal complement cascade drives bone cancer pain via C3R mediated microglial activation
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2018.06.011
Abstract: Activation of spinal cord microglia is crucial for the development of bone cancer pain (BCP). The essential signal between neuronal excitability and microglial activation is not fully understood. In the present study, carcinoma implantation into… read more here.
Keywords: complement cascade; complement; activation; cancer ... See more keywords
α2,6-Sialylation Is Upregulated in Severe COVID-19, Implicating the Complement Cascade
Sign Up to like & getrecommendations! Published in 2022 at "ACS Infectious Diseases"
DOI: 10.1021/acsinfecdis.2c00421
Abstract: Better understanding of the molecular mechanisms underlying COVID-19 severity is desperately needed in current times. Although hyper-inflammation drives severe COVID-19, precise mechanisms triggering this cascade and what role glycosylation might play therein are unknown. Here… read more here.
Keywords: severe covid; sialylation; sialylation upregulated; complement cascade ... See more keywords
Activation of the complement cascade enhances motility of leukemic cells by downregulating expression of HO-1
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia"
DOI: 10.1038/leu.2016.198
Abstract: As a crucial arm of innate immunity, the complement cascade (ComC) is involved both in mobilization of normal hematopoietic stem/progenitor cells (HSPCs) from bone marrow (BM) into peripheral blood and in their homing to BM.… read more here.
Keywords: cell; complement cascade; leukemic cells; enhances motility ... See more keywords
Protein therapeutics and their lessons: Expect the unexpected when inhibiting the multi‐protein cascade of the complement system
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DOI: 10.1111/imr.13164
Abstract: Over a century after the discovery of the complement system, the first complement therapeutic was approved for the treatment of paroxysmal nocturnal hemoglobinuria (PNH). It was a long‐acting monoclonal antibody (aka 5G1‐1, 5G1.1, h5G1.1, and… read more here.
Keywords: complement; therapeutics lessons; complement cascade; complement system ... See more keywords
Inhibition of the C5a-C5aR Axis By the L-Aptamer Aon-D21 As a New Strategy to Ameliorate Uncontrolled Migration/Motility of Hematopoietic Stem Cells - Potential Therapeutic Implications for Paroxysmal Nocturnal Hemoglobinuria
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood.v130.suppl_1.1188.1188
Abstract: Background. Several mechanisms have been postulated for orchestrating the mobilization of hematopoietic stem/progenitor cells (HSPCs), and it has been proposed that activation of the complement cascade plays a crucial role in the initiation and execution… read more here.
Keywords: c5ar; aon d21; complement cascade; motility ... See more keywords
Targeting the Complement Cascade for Treatment of Dry Age-Related Macular Degeneration
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DOI: 10.3390/biomedicines10081884
Abstract: Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss in the elderly population. AMD is characterized in its late form by neovascularization (wet type) or geographic atrophy of the retinal pigment epithelium… read more here.
Keywords: related macular; age related; macular degeneration; cascade ... See more keywords