Hexamerization-enhanced CD20 antibody mediates complement-dependent cytotoxicity in serum genetically deficient in C9.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical immunology"
DOI: 10.1016/j.clim.2017.05.016
Abstract: We examined complement-dependent cytotoxicity (CDC) by hexamer formation-enhanced CD20 mAb Hx-7D8 of patient-derived chronic lymphocytic leukemia (CLL) cells that are relatively resistant to CDC. CDC was analyzed in normal human serum (NHS) and serum from… read more here.
Keywords: complement dependent; dependent cytotoxicity; enhanced cd20; cdc ... See more keywords
Complement-dependent, monoclonal gammapathy-associated thrombotic microangiopathy.
Sign Up to like & getrecommendations! Published in 2017 at "Kidney international"
DOI: 10.1016/j.kint.2017.04.039
Abstract: To the Editor: We commend Ravindran et al. for providing a novel insight on the connection between monoclonal gammapathy and thrombotic microangiopathy (TMA). How monoclonal Ig may facilitate the occurrence of TMA remains debatable. Next… read more here.
Keywords: complement dependent; thrombotic microangiopathy; monoclonal gammapathy; dependent monoclonal ... See more keywords
Successful kidney transplantation across a positive complement-dependent cytotoxicity crossmatch by using C1q assay-directed, bortezomib-assisted desensitization
Sign Up to like & getrecommendations! Published in 2017 at "Medicine"
DOI: 10.1097/md.0000000000008145
Abstract: Rationale: Human leukocyte antigen (HLA) is the major immunologic barrier in kidney transplantation (KT). Various desensitization protocols to overcome the HLA barrier have increased the opportunity for transplantation in sensitized patients. In addition, technological advances… read more here.
Keywords: complement dependent; kidney transplantation; dependent cytotoxicity; transplantation ... See more keywords
Trastuzumab/pertuzumab combination therapy stimulates antitumor responses through complement-dependent cytotoxicity and phagocytosis
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.155636
Abstract: Two HER2-specific mAbs, trastuzumab and pertuzumab (T+P), combined with chemotherapy comprise standard-of-care treatment for advanced HER2+ breast cancers (BC). While this antibody combination is highly effective, its synergistic mechanism-of-action (MOA) remains incompletely understood. Past studies… read more here.
Keywords: complement dependent; her2; combination; therapy ... See more keywords
Complement-Dependent Mechanisms and Interventions in Periodontal Disease
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DOI: 10.3389/fimmu.2019.00406
Abstract: Periodontitis is a prevalent inflammatory disease that leads to the destruction of the tooth-supporting tissues. Current therapies are not effective for all patients and this oral disease continues to be a significant public health and… read more here.
Keywords: periodontal disease; dependent mechanisms; complement dependent; mechanisms interventions ... See more keywords
Bispecific mAb2 Antibodies Targeting CD59 Enhance the Complement-Dependent Cytotoxicity Mediated by Rituximab
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23095208
Abstract: Inhibition of complement activation via the overexpression of complement-regulatory proteins (CRPs), most notably CD46, CD55 and CD59, is an efficient mechanism of disguise of cancer cells from a host immune system. This phenomenon extends to… read more here.
Keywords: cd20; complement dependent; complement; dependent cytotoxicity ... See more keywords
Dengue-Immune Humans Have Higher Levels of Complement-Independent Enhancing Antibody than Complement-Dependent Neutralizing Antibody.
Sign Up to like & getrecommendations! Published in 2017 at "Japanese journal of infectious diseases"
DOI: 10.7883/yoken.jjid.2016.379
Abstract: Dengue is the most important arboviral disease worldwide. We previously reported that most inhabitants of dengue-endemic countries who are naturally immune to the disease have infection-enhancing antibodies whose in vitro activity does not decrease in… read more here.
Keywords: complement dependent; antibody; complement independent; independent enhancing ... See more keywords