Altered expression patterns of complement factor H and miR‐146a genes in acute‐chronic phases in experimental autoimmune encephalomyelitis mouse
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28583
Abstract: Considerable advances have been made in identification of the involvement of immune modulators in diseases. There is growing evidence on the role of complement pathway in pathogenesis and course of multiple sclerosis (MS). Moreover, it… read more here.
Keywords: chronic phases; mir 146a; complement factor; expression ... See more keywords
Common complement factor H polymorphisms are linked with periodontitis in elderly patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Periodontology"
DOI: 10.1002/jper.22-0005
Abstract: Abstract Background In our recent genome‐wide association study, we found that genetic polymorphisms in the complement factor H (CFH) gene and S100A gene region are strongly associated with serum matrix metalloproteinase 8 (MMP‐8) concentration and… read more here.
Keywords: polymorphisms; complement factor; s100a12 mmp; s100a8 s100a12 ... See more keywords
A novel, multiplexed targeted mass spectrometry assay for quantification of complement factor H (CFH) variants and CFH‐related proteins 1–5 in human plasma
Sign Up to like & getrecommendations! Published in 2017 at "PROTEOMICS"
DOI: 10.1002/pmic.201600237
Abstract: Age‐related macular degeneration (AMD) is a leading cause of visual loss among older adults. Two variants in the complement factor H (CFH) gene, Y402H and I62V, are strongly associated with risk of AMD. CFH is… read more here.
Keywords: cfh variants; factor cfh; cfh; complement factor ... See more keywords
Detection of Complement Factor B Autoantibodies by ELISA.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1016-9_14
Abstract: Antibodies to autoantigens are implicated in a large number of diseases. Such autoantibodies may cause pathological activation of complement, an ancient humoral recognition and effector system of innate immunity; in addition, complement components or regulators… read more here.
Keywords: detection complement; autoantibodies elisa; complement factor; factor autoantibodies ... See more keywords
Circulating complement factor H-related protein 5 levels contribute to development and progression of IgA nephropathy.
Sign Up to like & getrecommendations! Published in 2018 at "Kidney international"
DOI: 10.1016/j.kint.2018.02.023
Abstract: IgA nephropathy (IgAN) is a disease associated with activation of the complement system. But the factors influencing complement activation in IgAN are not fully understood. Complement factor H (FH) is an essential negative regulator of… read more here.
Keywords: iga nephropathy; complement factor; progression; factor related ... See more keywords
Successful 7-Year Eculizumab Treatment of Plasmapheresis-Resistant Recurrent Atypical Hemolytic-Uremic Syndrome due to Complement Factor H Hybrid Gene: A Case Report.
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2018.02.012
Abstract: Atypical hemolytic-uremic syndrome (aHUS) is an extremely rare disease, and up to 70% of the patients have a genetic mutation in the encoding components of complement activation or anti-complement factor H autoantibodies. The risk of… read more here.
Keywords: eculizumab; eculizumab treatment; hybrid gene; complement factor ... See more keywords
Association of central serous chorioretinopathy with single nucleotide polymorphisms in complement factor H gene in Iranian population
Sign Up to like & getrecommendations! Published in 2021 at "Eye"
DOI: 10.1038/s41433-021-01579-x
Abstract: To investigate the association of two different single nucleotide polymorphisms (SNPs) in the complement factor H (CFH) gene with central serous chorioretinopathy (CSCR) in the Iranian population. This is a case-control study with 95 participants… read more here.
Keywords: cscr; complement factor; nucleotide polymorphisms; single nucleotide ... See more keywords
Association of combined complement factor H Y402H and ARMS2/LOC387715 A69S polymorphisms with age-related macular degeneration: an updated meta-analysis
Sign Up to like & getrecommendations! Published in 2020 at "Ophthalmic Genetics"
DOI: 10.1080/13816810.2020.1765396
Abstract: ABSTRACT Background Complement factor H (CFH) Y402 H (rs1061170) and age-related maculopathy susceptibility2 (ARMS2)/LOC387715 A69 S (rs10490924) polymorphisms shown to have significant association with AMD. In this meta-analysis, we updated and pooled the results of… read more here.
Keywords: complement factor; analysis; association; arms2 loc387715 ... See more keywords
Rare complement factor I variants associated with reduced macular thickness and age-related macular degeneration in the UK Biobank
Sign Up to like & getrecommendations! Published in 2022 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddac060
Abstract: Abstract To evaluate potential diagnostic and therapeutic biomarkers for age-related macular degeneration (AMD), we identified 8433 UK Biobank participants with rare complement Factor I gene (CFI) variants, 579 with optical coherence tomography-derived macular thickness data.… read more here.
Keywords: age related; variants associated; factor; macular thickness ... See more keywords
P0391STUDY OF ANTI COMPLEMENT FACTOR H MEDIATED DISEASE AT A TERTIARY CARE CENTRE
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DOI: 10.1093/ndt/gfaa142.p0391
Abstract: To study the clinical profile and outcome of patients with anti complement factor H mediated disease at our centre. We conducted a prospective study over 24 months ( August 2016 to July 2018) to assess… read more here.
Keywords: factor; complement factor; anti complement; mediated disease ... See more keywords
The role of anti‐complement factor H antibodies in the development of atypical haemolytic uremic syndrome: a possible contribution to abnormality of platelet function
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Haematology"
DOI: 10.1111/bjh.16297
Abstract: Atypical haemolytic uremic syndrome (aHUS) is associated with complement system abnormality, such as production of complement factor H (CFH) autoantibodies. The growing evidence indicates complement overactivation on platelets is intimately involved in aHUS pathogenesis, besides… read more here.
Keywords: haemolytic uremic; uremic syndrome; complement factor; anti cfh ... See more keywords