Tumor‐shed antigen CA125 blocks complement‐mediated killing via suppression of C1q‐antibody binding
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201847707
Abstract: C1q‐engagement with IgG and IgM type antibodies is the initiating step of classical complement‐mediated immunity. The tumor shed antigen CA125 has been reported to have immunosuppressive effects on host tumor responses as well as commercially… read more here.
Keywords: ca125; antibody; c1q; complement ... See more keywords
Glucocorticoid receptor selectively mediates stress‐induced suppression of innate immunity in the House Sparrow, Passer domesticus
Sign Up to like & getrecommendations! Published in 2018 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2018.03.006
Abstract: &NA; Stress‐induced inhibition of innate immune activity is widespread in free‐ranging birds, but the mechanisms that are responsible for this inhibition are poorly understood. We previously demonstrated that an increase in plasma corticosterone (CORT), the… read more here.
Keywords: glucocorticoid; stress induced; induced suppression; stress ... See more keywords
Targeting complement-mediated immunoregulation for cancer immunotherapy.
Sign Up to like & getrecommendations! Published in 2018 at "Seminars in immunology"
DOI: 10.1016/j.smim.2018.02.003
Abstract: Complement was initially discovered as an assembly of plasma proteins "complementing" the cytolytic activity of antibodies. However, our current knowledge places this complex system of several plasma proteins, receptors, and regulators in the center of… read more here.
Keywords: mediated immunoregulation; functions complement; targeting complement; complement ... See more keywords
The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development
Sign Up to like & getrecommendations! Published in 2020 at "Nature neuroscience"
DOI: 10.1038/s41593-020-0672-0
Abstract: Complement-mediated synapse elimination has emerged as an important process in both brain development and neurological diseases, but whether neurons express complement inhibitors that protect synapses against complement-mediated synapse elimination remains unknown. Here, we show that… read more here.
Keywords: elimination; srpx2; synapse elimination; complement mediated ... See more keywords
Klebsiella LPS O1-antigen prevents complement-mediated killing by inhibiting C9 polymerization
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-71487-z
Abstract: The Gram-negative bacterium Klebsiella pneumoniae is an important human pathogen. Its treatment has been complicated by the emergence of multi-drug resistant strains. The human complement system is an important part of our innate immune response… read more here.
Keywords: lps antigen; complement mediated; antigen prevents; mediated killing ... See more keywords
Complement-Mediated Disorders in Pregnancy.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in chronic kidney disease"
DOI: 10.1053/j.ackd.2020.01.002
Abstract: Complement-mediated disorders in pregnancy span a large spectrum and have been implicated in all three complement pathways: classical, lectin, and alternative. Our understanding of these disorders in recent years has advanced due to a better… read more here.
Keywords: disorders pregnancy; complement; mediated disorders; complement mediated ... See more keywords
Mechanisms of Complement-Mediated Damage in Hematological Disorders.
Sign Up to like & getrecommendations! Published in 2018 at "Seminars in hematology"
DOI: 10.1053/j.seminhematol.2018.02.003
Abstract: The complement cascade is an ancient defense system that destroys and eliminates threats to normal homeostasis in the bloodstream and tissues. Although multiple controls keep complement in check to minimize innocent bystander injury to normal… read more here.
Keywords: mediated damage; hematological disorders; complement; damage hematological ... See more keywords
HIF Stabilizer Desidustat Protects against Complement-Mediated Diseases
Sign Up to like & getrecommendations! Published in 2024 at "Drug Research"
DOI: 10.1055/a-2347-9919
Abstract: Abstract Complement cascade is a defence mechanism useful for eliminating pathogenic microorganisms and damaged cells. However, activation of alternative complement system can also cause inflammation and promote kidney and retinal disease progression. Inflammation causes tissue… read more here.
Keywords: complement mediated; desidustat; mediated diseases; complement ... See more keywords
Complement Inhibitors in the Management of Complement-Mediated Hemolytic Uremic Syndrome and Paroxysmal Nocturnal Hemoglobinuria
Sign Up to like & getrecommendations! Published in 2023 at "American Journal of Therapeutics"
DOI: 10.1097/mjt.0000000000001609
Abstract: Background: Complement-mediated HUS (CM-HUS) and paroxysmal nocturnal hemoglobinuria (PNH) are rare hematologic disorders that cause dysregulation and hyperactivation of the complement system. Historically, treatment of CM-HUS involved plasma exchange (PLEX), often with limited benefit and… read more here.
Keywords: complement; nocturnal hemoglobinuria; complement mediated; paroxysmal nocturnal ... See more keywords
First‐in‐human study with SAR445088: A novel selective classical complement pathway inhibitor
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and Translational Science"
DOI: 10.1111/cts.13481
Abstract: SAR445088 is an anti‐C1s humanized monoclonal antibody that inhibits activated C1s in the proximal portion of the classical complement system and has the potential to provide clinical benefit in the treatment of complement‐mediated diseases. A… read more here.
Keywords: complement; complement pathway; complement mediated; classical complement ... See more keywords
Deciphering the role of the conjugate's phycoerythrin label in complement-mediated interference occurring in HLA single antigen Luminex bead assays.
Sign Up to like & getrecommendations! Published in 2022 at "HLA"
DOI: 10.1111/tan.14628
Abstract: Complement-mediated interference is a well described phenomenon in single antigen bead (SAB) Luminex assay that leads to falsely low or negative results for anti-HLA antibody (Ab). In a context of high amount of Ab, the… read more here.
Keywords: role; mediated interference; interference; single antigen ... See more keywords